PMID- 15843216
OWN - NLM
STAT- MEDLINE
DCOM- 20050815
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 43
IP  - 2
DP  - 2005
TI  - Measurement of reticulocyte and red blood cell indices in patients with iron 
      deficiency anemia and beta-thalassemia minor.
PG  - 195-7
AB  - New parameters correlated with the hemoglobin content in reticulocytes (RET-Y) 
      and in red blood cells (RBC-Y) have been suggested as helpful in diagnosing iron 
      deficiency anemia. We have studied RET-Y and RBC-Y indices in two groups of 
      patients with microcytosis to verify if these parameters could be used to 
      differentiate iron deficiency anemia from beta-thalassemia minor. Blood samples 
      from 33 iron-deficient patients, 25 beta-thalassemic minor patients and 50 normal 
      individuals were analyzed on a Sysmex XE-2100 instrument. A significant 
      difference was observed in reticulocyte counting and immature reticulocyte 
      fraction between iron deficiency anemia and beta-thalassemia minor groups, but 
      not in RBC-X and RET-Y parameters. Reticulocyte counting was higher in 
      beta-thalassemia minor and the immature reticulocyte fraction was higher in 
      severe iron deficiency anemia. The ratio RET-Y/mean cell volume was tested and 
      was significantly different when beta-thalassemia minor was compared with mild 
      and severe iron deficiency anemia, and showed better performance than the Mentzer 
      ratio and the Green and King function. A great overlap of RET-Y and RBC-Y 
      individual values was observed in both groups of microcytic anemias; we conclude 
      that these new indices may be used with caution as indicative of iron deficiency, 
      mainly in populations where beta-thalassemia minor is frequent.
FAU - Noronha, Jose F A
AU  - Noronha JF
AD  - Department of Clinical Pathology, School of Medical Sciences, State University of 
      Campinas, Sao Paulo, Brazil.
FAU - Grotto, Helena Z W
AU  - Grotto HZ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Anemia, Iron-Deficiency/blood/*pathology
MH  - Cell Count
MH  - Diagnosis, Differential
MH  - Erythrocyte Indices
MH  - Erythrocytes/*pathology
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Reticulocytes/*pathology
MH  - Sensitivity and Specificity
MH  - beta-Thalassemia/blood/*pathology
EDAT- 2005/04/22 09:00
MHDA- 2005/08/16 09:00
CRDT- 2005/04/22 09:00
PHST- 2005/04/22 09:00 [pubmed]
PHST- 2005/08/16 09:00 [medline]
PHST- 2005/04/22 09:00 [entrez]
AID - 10.1515/CCLM.2005.033 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2005;43(2):195-7. doi: 10.1515/CCLM.2005.033.