PMID- 15843267
OWN - NLM
STAT- MEDLINE
DCOM- 20050728
LR  - 20061115
IS  - 0300-5577 (Print)
IS  - 0300-5577 (Linking)
VI  - 33
IP  - 2
DP  - 2005
TI  - Amniotic fluid lamellar body counts for the determination of fetal lung maturity: 
      an update.
PG  - 156-60
AB  - AIM: To reassess the cut-off value for lamellar body counts (LBs) for fetal lung 
      maturity (FLM) over a 10-year study period. PATIENTS AND METHODS: 178 pregnancies 
      were selected under strict inclusion criteria and delivered within 48 h from 
      amniocentesis. FLM was determined by amniotic fluid LBs in centrifuged samples 
      (300 x g for 10 min) in a commercially available Coulter Counter. Cases beyond 37 
      weeks were excluded. RESULTS: Mean gestational age was 33.5+/-3.0 weeks at 
      amniocentesis and 33.7+/-3.0 weeks at birth. After reassessing the best 
      compromise between sensitivity and specificity for all cases using the receiver 
      operating characteristic (ROC) procedure, an FLM cut-off value of < or = 
      22,000/microL was obtained. Diagnostic accuracy (and confidence interval, CI) 
      was: sensitivity, 73% (60.0-83.6%); specificity, 81.7% (CI 73.6-88.1%); positive 
      predictive value, 66.2%; and negative predictive value, 86.0%. CONCLUSION: No 
      significant change in FLM cut-off for LBs was found when comparing the value from 
      this study and the results of our earlier report presented in 1996 (< or = 22,000 
      vs. < or = 20,000/microL), although the new value may be more accurate, since it 
      is based on neonatal outcome with the exclusion of cases in which the diagnosis 
      of FLM is seldom warranted, i.e., > 37 weeks' gestational age.
FAU - Piazze, Juan J
AU  - Piazze JJ
AD  - Institute of Gynecology, Perinatology and Child Health, University La Sapienza, 
      Rome, Italy.
FAU - Maranghi, Luca
AU  - Maranghi L
FAU - Cerekja, Albana
AU  - Cerekja A
FAU - Meloni, Paolo
AU  - Meloni P
FAU - Gioia, Stefano
AU  - Gioia S
FAU - Fumian, Luisa
AU  - Fumian L
FAU - Cosmi, Ermelando V
AU  - Cosmi EV
FAU - Anceschi, Maurizio M
AU  - Anceschi MM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
RN  - 0 (Phospholipids)
SB  - IM
MH  - Amniocentesis
MH  - Amniotic Fluid/*chemistry
MH  - Female
MH  - Fetal Organ Maturity/*physiology
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Lung/*embryology
MH  - Phospholipids/analysis
MH  - Pregnancy
MH  - Prenatal Diagnosis/methods
MH  - Respiratory Distress Syndrome, Newborn/diagnosis/prevention & control
EDAT- 2005/04/22 09:00
MHDA- 2005/07/29 09:00
CRDT- 2005/04/22 09:00
PHST- 2005/04/22 09:00 [pubmed]
PHST- 2005/07/29 09:00 [medline]
PHST- 2005/04/22 09:00 [entrez]
AID - 10.1515/JPM.2005.029 [doi]
PST - ppublish
SO  - J Perinat Med. 2005;33(2):156-60. doi: 10.1515/JPM.2005.029.