PMID- 1584336
OWN - NLM
STAT- MEDLINE
DCOM- 19920618
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 55
IP  - 5
DP  - 1992 May
TI  - Asymmetry of brain aromatase activity: region- and sex-specific developmental 
      patterns.
PG  - 512-8
AB  - Developmental patterns of aromatase activity (AA) were characterized in 
      individual forebrain regions of the rat at gestational day (GD) 22 and postnatal 
      days (PN) 6 and 15. Aromatase activity was measured separately in homogenates of 
      left and right preoptic area, anterior amygdaloid area, medial amygdaloid 
      nucleus, anterior hypothalamic area and posterior hypothalamic area, by the 
      tritiated water method with [1 beta-3H]-androstenedione as a substrate. Region- 
      and sex-dependent asymmetries of AA with either left-to-right or right-to-left 
      gradients were found. They change between GD22 and PN6 and PN15 according to 
      region-specific patterns. Thus, AA of the male medial amygdaloid nucleus of the 
      left side is higher at GD22, lower at PN6 and equal to the right side at PN15; in 
      females, AA of the left side is lower than AA of the right side at GD22 and 
      higher at PN6 and PN15. In preoptic area, a side difference (left side higher) 
      was only detected in males. Asymmetries may result from differences in the 
      expression of the enzyme by individual cell groups, or from differences in the 
      number of cells per area expressing the enzyme. In either case, the 
      stage-dependent patterns of asymmetry in AA would be expected to influence sex 
      steroid-dependent differentiation processes in individual forebrain areas.
FAU - von Ziegler, N I
AU  - von Ziegler NI
AD  - Institute of Pharmacology, University of Zurich, Switzerland.
FAU - Lichtensteiger, W
AU  - Lichtensteiger W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Amygdala/embryology/enzymology/growth & development
MH  - Animals
MH  - Aromatase/*metabolism
MH  - Brain/embryology/enzymology/*growth & development
MH  - Female
MH  - Hypothalamus, Anterior/embryology/enzymology/growth & development
MH  - Hypothalamus, Posterior/embryology/enzymology/growth & development
MH  - Male
MH  - Preoptic Area/embryology/enzymology/growth & development
MH  - Rats
MH  - *Sex Characteristics
MH  - Tissue Distribution
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.1159/000126165 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1992 May;55(5):512-8. doi: 10.1159/000126165.