PMID- 15844828 OWN - NLM STAT- MEDLINE DCOM- 20050617 LR - 20220316 IS - 0192-415X (Print) IS - 0192-415X (Linking) VI - 33 IP - 1 DP - 2005 TI - Hawthorn: potential roles in cardiovascular disease. PG - 1-10 AB - Hawthorn (Crataegus) may play a role in the prevention and treatment of cardiovascular diseases such as hypertension, hyperlipidemia, and in particular, congestive heart failure. Evidence is accumulating that hawthorn may induce anti-ischemia/reperfusion-injury, anti-arrhythmic, hypolipidemic and hypotensive effects. These beneficial effects may in part be due to the presence of antioxidant flavonoid components. While a number of studies have been performed to evaluate the clinical efficacy of hawthorn, an international, multicenter, prospective clinical study including a large number of New York Heart Association (NYHA) class II/III heart failure patients is ongoing to test hawthorn's long-term therapeutic effects. Further clinical trials as well as pharmacokinetic and mechanistic studies are needed to explore and confirm its effectiveness, safety and pharmacological mechanism. FAU - Chang, Wei-Tien AU - Chang WT AD - Emergency Resuscitation Center, Department of Medicine Section of Emergency Medicine, University of Chicago, IL 60637, USA. FAU - Dao, Jenny AU - Dao J FAU - Shao, Zuo-Hui AU - Shao ZH LA - eng PT - Journal Article PT - Review PL - Singapore TA - Am J Chin Med JT - The American journal of Chinese medicine JID - 7901431 RN - 0 (Plant Preparations) SB - IM MH - Cardiovascular Diseases/*drug therapy MH - *Crataegus MH - Humans MH - *Medicine, Chinese Traditional MH - *Phytotherapy MH - Plant Preparations/*therapeutic use RF - 40 EDAT- 2005/04/23 09:00 MHDA- 2005/06/18 09:00 CRDT- 2005/04/23 09:00 PHST- 2005/04/23 09:00 [pubmed] PHST- 2005/06/18 09:00 [medline] PHST- 2005/04/23 09:00 [entrez] AID - S0192415X05002606 [pii] AID - 10.1142/S0192415X05002606 [doi] PST - ppublish SO - Am J Chin Med. 2005;33(1):1-10. doi: 10.1142/S0192415X05002606.