PMID- 15845584
OWN - NLM
STAT- MEDLINE
DCOM- 20050912
LR  - 20181113
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 565
IP  - Pt 3
DP  - 2005 Jun 15
TI  - Timing-dependent plasticity in human primary somatosensory cortex.
PG  - 1039-52
AB  - Animal experiments suggest that cortical sensory representations may be 
      remodelled as a consequence of changing synaptic efficacy by timing-dependent 
      associative neuronal activity. Here we describe a timing-based associative form 
      of plasticity in human somatosensory cortex. Paired associative stimulation (PAS) 
      was performed by combining repetitive median nerve stimulation with transcranial 
      magnetic stimulation (TMS) over the contralateral postcentral region. PAS 
      increased exclusively the amplitude of the P25 component of the median 
      nerve-evoked somatosensory-evoked potential (MN-SSEP), which is probably 
      generated in the superficial cortical layers of area 3b. SSEP components 
      reflecting neuronal activity in deeper cortical layers (N20 component) or 
      subcortical regions (P14 component) remained constant. PAS-induced enhancement of 
      P25 amplitude displayed topographical specificity both for the recording (MN-SSEP 
      versus tibial nerve-SSEP) and the stimulation (magnetic stimulation targeting 
      somatosensory versus motor cortex) arrangements. Modulation of P25 amplitude was 
      confined to a narrow range of interstimulus intervals (ISIs) between the MN pulse 
      and the TMS pulse, and the sign of the modulation changed with ISIs differing by 
      only 15 ms. The function describing the ISI dependence of PAS effects on 
      somatosensory cortex resembled one previously observed in motor cortex, shifted 
      by approximately 7 ms. The findings suggest a simple model of modulation of 
      excitability in human primary somatosensory cortex, possibly by mechanisms 
      related to the spike-timing-dependent plasticity of neuronal synapses located in 
      upper cortical layers.
FAU - Wolters, Alexander
AU  - Wolters A
AD  - Human Cortical Physiology Laboratory, Department of Neurology, University of 
      Rostock, Germany.
FAU - Schmidt, Arne
AU  - Schmidt A
FAU - Schramm, Axel
AU  - Schramm A
FAU - Zeller, Daniel
AU  - Zeller D
FAU - Naumann, Markus
AU  - Naumann M
FAU - Kunesch, Erwin
AU  - Kunesch E
FAU - Benecke, Reiner
AU  - Benecke R
FAU - Reiners, Karlheinz
AU  - Reiners K
FAU - Classen, Joseph
AU  - Classen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050421
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Adult
MH  - Afferent Pathways/physiology
MH  - Electroencephalography
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Median Nerve/physiology
MH  - Middle Aged
MH  - Neuronal Plasticity/*physiology
MH  - Somatosensory Cortex/*physiology
MH  - Time Factors
PMC - PMC1464551
EDAT- 2005/04/23 09:00
MHDA- 2005/09/13 09:00
PMCR- 2006/06/15
CRDT- 2005/04/23 09:00
PHST- 2005/04/23 09:00 [pubmed]
PHST- 2005/09/13 09:00 [medline]
PHST- 2005/04/23 09:00 [entrez]
PHST- 2006/06/15 00:00 [pmc-release]
AID - jphysiol.2005.084954 [pii]
AID - 10.1113/jphysiol.2005.084954 [doi]
PST - ppublish
SO  - J Physiol. 2005 Jun 15;565(Pt 3):1039-52. doi: 10.1113/jphysiol.2005.084954. Epub 
      2005 Apr 21.