PMID- 15845682
OWN - NLM
STAT- MEDLINE
DCOM- 20050526
LR  - 20210902
IS  - 0003-2999 (Print)
IS  - 0003-2999 (Linking)
VI  - 100
IP  - 5
DP  - 2005 May
TI  - The quantitative distinction between train-of-four "counts of 2" and posttetanic 
      "counts of 2" evidenced by a stable paralysis/stable infusion rate method in 
      anesthetized patients receiving mivacurium.
PG  - 1348-1351
LID - 10.1213/01.ANE.0000148693.12874.22 [doi]
AB  - In this study we quantitatively evaluated, by a stable paralysis/stable infusion 
      rate method, the difference between two standardized paralysis 
      levels--train-of-four (TOF) count of 2 responses and posttetanic count (PTC) of 
      2. Ten ASA physical status I-II consenting adult patients scheduled for elective 
      surgery were anesthetized (sufentanil/propofol), tracheally intubated, 
      mechanically normoventilated with a fixed O(2)/air mixture, and normothermic; 
      oropharynx and thenar temperatures were maintained above 36 degrees and 32.5 
      degrees C, respectively. After partial recovery from 200 microg/kg mivacurium 
      (MIV), stable tactile TOF and PTC counts of 2 paralysis levels were induced on 
      the adductor pollicis muscle by manual adjustments of an infusion pump containing 
      MIV. The paralysis levels and the infusion rates were considered as stable once 
      they remained constant at 4 consecutive time points separated by 5 min each. 
      Infusion rates observed were: TOF count 2-6 (2-11) and PTC 2-17 (3-18) microg . 
      kg(-1) . min(-1) (P < 0.001; Wilcoxon's paired comparison test). Under the 
      present conditions, obtaining and maintaining a PTC of 2 requires MIV infusion 
      rates far in excess of the "standard" recommendations mentioned in the literature 
      for MIV infusion management.
FAU - d'Hollander, A A
AU  - d'Hollander AA
AD  - Service d' Anesthesiologie, Hopital Universitaire de Geneve, Geneve, Switzerland.
FAU - Pytel, A V
AU  - Pytel AV
FAU - Merzouga, B M
AU  - Merzouga BM
FAU - Klopfenstein, C -E
AU  - Klopfenstein C-
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
RN  - 0 (Isoquinolines)
RN  - 0 (Neuromuscular Nondepolarizing Agents)
RN  - 77D66S9Q93 (Mivacurium)
SB  - IM
MH  - Adult
MH  - Anesthesia
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Isoquinolines/*administration & dosage/pharmacology
MH  - Male
MH  - Middle Aged
MH  - Mivacurium
MH  - Muscle Relaxation/*drug effects
MH  - Neuromuscular Nondepolarizing Agents/*pharmacology
EDAT- 2005/04/23 09:00
MHDA- 2005/05/27 09:00
CRDT- 2005/04/23 09:00
PHST- 2005/04/23 09:00 [pubmed]
PHST- 2005/05/27 09:00 [medline]
PHST- 2005/04/23 09:00 [entrez]
AID - 00000539-200505000-00025 [pii]
AID - 10.1213/01.ANE.0000148693.12874.22 [doi]
PST - ppublish
SO  - Anesth Analg. 2005 May;100(5):1348-1351. doi: 10.1213/01.ANE.0000148693.12874.22.