PMID- 15846572
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20191109
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 42
IP  - 2
DP  - 2005 Apr
TI  - Complex interactions: the immunogenetics of human leukocyte antigen and killer 
      cell immunoglobulin-like receptors.
PG  - 65-75
AB  - The killer cell immunoglobulin-like receptors (KIR) for human leukocyte antigen 
      (HLA) modulate innate and adaptive immunity by controlling effector cells. HLA 
      and KIR are encoded in genomic regions that have complex organization and exhibit 
      exceptional diversity within and among human population groups. This diversity is 
      likely to have arisen to combat a constantly evolving pathogen challenge. 
      Numerous variations influence the expression level or function of KIR molecules 
      and can affect their interaction with HLA, with important implications for the 
      immune response. The functional variety of natural immune responses that are 
      controlled by HLA and KIR interactions is genetically determined and maintained 
      by natural selection.
FAU - Norman, Paul J
AU  - Norman PJ
AD  - Departments of Structural Biology and Microbiology, Stanford University School of 
      Medicine, 299 Campus Drive West, Stanford, CA 94305, USA. 
      paul.norman@stanford.edu
FAU - Parham, Peter
AU  - Parham P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Animals
MH  - Cell Communication/genetics/immunology
MH  - Gene Expression Regulation/*immunology
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Immunity, Cellular/*genetics
MH  - Immunogenetics
MH  - Killer Cells, Natural/immunology
MH  - *Polymorphism, Genetic
MH  - Receptors, Immunologic/*genetics
MH  - Receptors, KIR
RF  - 51
EDAT- 2005/04/23 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/04/23 09:00
PHST- 2005/04/23 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/04/23 09:00 [entrez]
AID - S0037196305000119 [pii]
AID - 10.1053/j.seminhematol.2005.01.007 [doi]
PST - ppublish
SO  - Semin Hematol. 2005 Apr;42(2):65-75. doi: 10.1053/j.seminhematol.2005.01.007.