PMID- 15846573
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20191109
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 42
IP  - 2
DP  - 2005 Apr
TI  - Human leukocyte antigen matching in unrelated donor hematopoietic cell 
      transplantation.
PG  - 76-84
AB  - Hematopoietic cell transplantation (HCT) from unrelated donors is a curative 
      therapy for many malignant and nonmalignant blood disorders. The success of 
      unrelated HCT is influenced by the degree of human leukocyte antigen (HLA) 
      compatibility between the donor and patient. When donor matching for HLA alleles 
      is feasible, overall transplant outcome is superior. The presence of 
      donor-recipient mismatching is associated with increased risk of post-transplant 
      complications including graft rejection, acute and chronic graft-versus-host 
      disease (GVHD), and mortality; these risks are increased with multiple HLA 
      mismatches. For the majority of patients who lack HLA-matched unrelated donors, 
      current research is focused on the identification of permissible HLA mismatches. 
      The influence of nongenetic factors on the tolerability of HLA mismatching has 
      recently become evident, demonstrating a need for the integration of both genetic 
      and nongenetic variables in donor selection.
FAU - Petersdorf, Effie W
AU  - Petersdorf EW
AD  - Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 
      Fairview Avenue N, Seattle, WA 98109, USA. spetersd@fhcrc.org
FAU - Malkki, Mari
AU  - Malkki M
LA  - eng
GR  - AI 33484/AI/NIAID NIH HHS/United States
GR  - CA 100019/CA/NCI NIH HHS/United States
GR  - CA 18029/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Donor Selection
MH  - Graft vs Host Disease/prevention & control
MH  - *HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation/mortality
MH  - Histocompatibility Testing
MH  - Humans
RF  - 63
EDAT- 2005/04/23 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/04/23 09:00
PHST- 2005/04/23 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/04/23 09:00 [entrez]
AID - S0037196305000090 [pii]
AID - 10.1053/j.seminhematol.2005.01.009 [doi]
PST - ppublish
SO  - Semin Hematol. 2005 Apr;42(2):76-84. doi: 10.1053/j.seminhematol.2005.01.009.