PMID- 15846574
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20191109
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 42
IP  - 2
DP  - 2005 Apr
TI  - Human leukocyte antigen matching in cord blood transplantation.
PG  - 85-90
AB  - Cord blood transplants are now widely used for allogeneic hematopoietic stem cell 
      transplants (HSCT) in patients with various hematologic disorders. One advantage 
      of this source of stem cells is the decrease of graft-versus-host disease (GVHD) 
      because of the immaturity of lymphocytes at birth. The role of human leukocyte 
      antigen (HLA) for donor search and post-transplant outcomes is not very well 
      described. The Eurocord Registry has analyzed more than 1,000 cases of unrelated 
      cord blood transplants (UCBT). Results show that HLA matching is important for 
      engraftment and graft versus leukemia but not for survival and GVHD. Allelic 
      matching for HLA-A, -B, -C, -DRB1, and -DQB1 shows that the number of mismatches 
      is very high and does not allow identification of prognostic factors. Contrary to 
      the criteria of donor choice for an unrelated bone marrow transplant where HLA 
      allelic matching is important, in the case of cord blood transplants the number 
      of nucleated cells infused is the most important predictor of success.
FAU - Gluckman, Eliane
AU  - Gluckman E
AD  - Department of Hematologie Bone Marrow Transplant, Eurocord, Institute of 
      Hematology, APHP Hospital Saint Louis, 1 Avenue Claude Vellefaux, 75475 Paris 
      Cedex 10, France. elaine.gluckman@sls.ap-hop-paris
FAU - Koegler, Gesine
AU  - Koegler G
FAU - Rocha, Vanderson
AU  - Rocha V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Cord Blood Stem Cell Transplantation
MH  - *Donor Selection
MH  - Graft vs Host Disease/mortality/prevention & control
MH  - Graft vs Leukemia Effect
MH  - *HLA Antigens
MH  - Histocompatibility Testing
MH  - Humans
RF  - 24
EDAT- 2005/04/23 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/04/23 09:00
PHST- 2005/04/23 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/04/23 09:00 [entrez]
AID - S0037196305000089 [pii]
AID - 10.1053/j.seminhematol.2005.01.006 [doi]
PST - ppublish
SO  - Semin Hematol. 2005 Apr;42(2):85-90. doi: 10.1053/j.seminhematol.2005.01.006.