PMID- 15846575
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20191109
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 42
IP  - 2
DP  - 2005 Apr
TI  - Natural killer cell receptors: regulating innate immune responses to hematologic 
      malignancy.
PG  - 91-103
AB  - Critical to innate immunity, the natural killer (NK) cell performs its function 
      of immunosurveillance through its recognition of altered or missing self on 
      damaged, infected, or transformed malignant cells. NK cell receptors responsible 
      for detection of human leukocyte antigen (HLA) class I and class I-like proteins 
      on potential target cells transmit inhibitory and activating signals that 
      integrate to determine NK cell function. Advances in the fields of NK cell 
      receptor biology and immunogenetics have enhanced our understanding of NK cell 
      target recognition and may now guide studies to determine NK cell effects in the 
      clinical setting. Analysis of NK cell receptor-ligand relationships, such as the 
      inhibitory killer immunoglobulin-like receptors (KIRs) and their HLA class I 
      ligands, has revealed the potential for NK cell-mediated benefit in allogeneic 
      hematopoietic stem cell transplantation for hematologic malignancies.
FAU - Hsu, Katharine C
AU  - Hsu KC
AD  - Department of Medicine and Immunology Program, Memorial Sloan-Kettering Cancer 
      Center, 1275 York Avenue, New York, NY 10021, USA. hsuk@mskcc.org
FAU - Dupont, Bo
AU  - Dupont B
LA  - eng
GR  - AI 49213/AI/NIAID NIH HHS/United States
GR  - AI 50193/AI/NIAID NIH HHS/United States
GR  - CA 08748/CA/NCI NIH HHS/United States
GR  - CA 23766/CA/NCI NIH HHS/United States
GR  - HL 070053/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Animals
MH  - *Cytotoxicity, Immunologic
MH  - Hematologic Neoplasms/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Receptors, Immunologic/*immunology
MH  - Receptors, KIR
RF  - 110
EDAT- 2005/04/23 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/04/23 09:00
PHST- 2005/04/23 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/04/23 09:00 [entrez]
AID - S0037196305000107 [pii]
AID - 10.1053/j.seminhematol.2005.01.010 [doi]
PST - ppublish
SO  - Semin Hematol. 2005 Apr;42(2):91-103. doi: 10.1053/j.seminhematol.2005.01.010.