PMID- 15846577
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20191109
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 42
IP  - 2
DP  - 2005 Apr
TI  - Human leukocyte antigen haploidentical hematopoietic stem cell transplantation: 
      indications and tentative outcomes in Japan.
PG  - 112-8
AB  - The stem cell banking system in Japan by the Japan Marrow Donor Program (JMDP) 
      and Japan Cord Blood Bank Network (JCBBN) has provided increased opportunities 
      for patients who might benefit from stem cell transplant from allogeneic sources 
      but who lack human leukocyte antigen (HLA)-matched related donors. Nevertheless, 
      most patients probably do not undergo transplantation because of the absence of 
      suitable stem cell sources. To fulfill this potential need, the outcomes of 
      transplants from HLA-mismatched relatives with or without T-cell depletion were 
      retrospectively analyzed: the rates of engraftment and survival were insufficient 
      in transplants with T-cell depletion, and the actual increase in transplantable 
      donor numbers was small because only a single locus mismatched donor was the 
      realistic choice in those without T-cell depletion. Since prophylaxis with 
      tacrolimus reduced the incidence of grade I-IV acute graft-versus-host disease 
      (GVHD) in HLA class I allele mismatched unrelated donors, we studied 
      transplantation from HLA one haploidentical family donors who showed 
      microchimerism of noninherited maternal antigens, without T-cell depletion but 
      with tacrolimus prophylaxis. The rates of engraftment and survival in this 
      circumstance were similar to those obtained with transplantation from HLA-matched 
      sibling donors.
FAU - Kodera, Yoshihisa
AU  - Kodera Y
AD  - Bone Marrow Transplantation Center, Japanese Red Cross Nagoya First Hospital, 
      3-35 Michishita-Cho, Nakamura-ku, Nagoya 453-8511, Japan. ykodera@mb.kcom.ne.jp
FAU - Nishida, Tetsuya
AU  - Nishida T
FAU - Ichinohe, Tatsuo
AU  - Ichinohe T
FAU - Saji, Hiroo
AU  - Saji H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - *Graft vs Host Disease/prevention & control
MH  - *HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation/statistics & numerical data
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Japan
MH  - Tacrolimus/therapeutic use
MH  - Transplantation, Homologous
RF  - 33
EDAT- 2005/04/23 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/04/23 09:00
PHST- 2005/04/23 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/04/23 09:00 [entrez]
AID - S0037196305000132 [pii]
AID - 10.1053/j.seminhematol.2005.02.001 [doi]
PST - ppublish
SO  - Semin Hematol. 2005 Apr;42(2):112-8. doi: 10.1053/j.seminhematol.2005.02.001.