PMID- 1584841
OWN - NLM
STAT- MEDLINE
DCOM- 19920618
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 41
IP  - 3
DP  - 1992 Mar
TI  - Ibotenic acid lesions of medial prefrontal cortex augment swim-stress-induced 
      locomotion.
PG  - 607-9
AB  - Locomotor activity of rats with sham or ibotenic acid lesions of the medial 
      prefrontal cortex (MPFC) was assessed after animals were exposed to a 15-min swim 
      or control stress. Swim-stress-induced locomotor activity was augmented in the 
      MPFC-lesioned rats. These and other data suggest that lesions of the MPFC are 
      followed by an exaggeration of the normal behavioral response to stress. 
      Dysregulation of dopamine transmission in the basal ganglia may be involved.
FAU - Jaskiw, G E
AU  - Jaskiw GE
AD  - Clinical Brain Disorders Branch, National Institutes of Mental Health Intramural 
      Research Program, NIMH Research Center, Washington, DC 20032.
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 2552-55-8 (Ibotenic Acid)
SB  - IM
MH  - Animals
MH  - Frontal Lobe/*drug effects/physiopathology
MH  - Ibotenic Acid/*toxicity
MH  - Locomotion/*physiology
MH  - Male
MH  - Motor Activity/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stress, Physiological/*physiopathology
MH  - Swimming
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
AID - 0091-3057(92)90380-X [pii]
AID - 10.1016/0091-3057(92)90380-x [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1992 Mar;41(3):607-9. doi: 10.1016/0091-3057(92)90380-x.