PMID- 15848509
OWN - NLM
STAT- MEDLINE
DCOM- 20050926
LR  - 20131121
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 37
IP  - 2
DP  - 2005 Mar
TI  - Baseline glomerular sclerosis influences morphological changes, but not level of 
      serum creatinine.
PG  - 709-11
AB  - The aim of this study was to investigate whether glomerular sclerosis (GS) at the 
      time of engraftment affects subsequent morphology and clinical course of renal 
      allografts. Eighty-one renal transplant recipients were recruited for this study. 
      Protocol biopsies of the renal allografts were performed at engraftment, as well 
      as at 1, 3, 5, and 7 years after transplantation. All cases were divided into 2 
      groups based on the presence of GS at engraftment, namely, non-GS and GS groups. 
      Morphological changes in the renal allografts were graded from 0 to 3+ based on 
      the severity of chronic allograft nephropathy (CAN) of the Banff classification 
      based on 5 factors: percentage of GS, extent of interstitial fibrosis, tubular 
      atrophy, arterial intimal thickening, and arteriolar hyalinosis. Furthermore, the 
      level of serum creatinine (s-Cr) at each year was examined by recipient age and 
      gender, donor age and gender, type of donor (living/cadaver), delayed graft 
      function, acute rejection within 1 year after transplantation, mean blood 
      pressure, and use of calcineurin inhibitors as well as the presence of GS at 
      engraftment. The extent of GS at engraftment significantly correlated with donor 
      age (P = .0038) but with a weak correlation coefficient. Although the severity of 
      CAN developed gradually in both non-GS and GS groups, differences in 
      morphological changes at engraftment between the 2 groups persisted throughout 7 
      years. Donor age and recipient gender influenced s-Cr significantly. In 
      conclusion, the presence of GS at engraftment aggravates subsequent morphological 
      changes and affects short-term but not long-term allograft prognosis.
FAU - Muramatsu, M
AU  - Muramatsu M
AD  - Department of Nephrology, Toho University School of Medicine, Tokyo, Japan. 
      masaki7419@hotmail.com
FAU - Miyagi, M
AU  - Miyagi M
FAU - Ishikawa, Y
AU  - Ishikawa Y
FAU - Itabashi, Y
AU  - Itabashi Y
FAU - Kawamura, T
AU  - Kawamura T
FAU - Arai, K
AU  - Arai K
FAU - Sakai, K
AU  - Sakai K
FAU - Aikawa, A
AU  - Aikawa A
FAU - Mizuiri, S
AU  - Mizuiri S
FAU - Ohara, T
AU  - Ohara T
FAU - Hasegawa, A
AU  - Hasegawa A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Creatinine/*blood
MH  - Follow-Up Studies
MH  - Glomerulosclerosis, Focal Segmental/*blood/*pathology
MH  - Humans
MH  - Kidney Transplantation/*pathology/*physiology
MH  - Middle Aged
MH  - Postoperative Complications/pathology
MH  - Regression Analysis
MH  - Time Factors
MH  - Transplantation, Homologous/pathology/physiology
EDAT- 2005/04/26 09:00
MHDA- 2005/09/27 09:00
CRDT- 2005/04/26 09:00
PHST- 2005/04/26 09:00 [pubmed]
PHST- 2005/09/27 09:00 [medline]
PHST- 2005/04/26 09:00 [entrez]
AID - S0041-1345(04)01476-9 [pii]
AID - 10.1016/j.transproceed.2004.12.038 [doi]
PST - ppublish
SO  - Transplant Proc. 2005 Mar;37(2):709-11. doi: 10.1016/j.transproceed.2004.12.038.