PMID- 15848524
OWN - NLM
STAT- MEDLINE
DCOM- 20050926
LR  - 20061115
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 37
IP  - 2
DP  - 2005 Mar
TI  - Effect of cytokines and chemokines (TGF-beta, TNF-alpha, IL-6, IL-10, MCP-1, 
      RANTES) gene polymorphisms in kidney recipients on posttransplantation outcome: 
      influence of donor-recipient match.
PG  - 764-6
AB  - Posttransplantation alloantigen-dependent and alloantigen-independent processes 
      are both mediated by cytokines and chemokines. Recently cytokines and chemokines, 
      as well as their receptors, have been shown to be highly polymorphic. The 
      cytokine and chemokine gene polymorphisms are associated with variable 
      production, activity, expression, or ligand-receptor affinity. The aim of our 
      study was to analyze the relation between selected cytokine and chemokine gene 
      polymorphisms in kidney donors and recipients as a function of donor-recipient 
      match and posttransplantation outcome. Polymorphisms transforming growth 
      factor-beta (TGF-beta); tumor necrosis factor-alpha (TNF-alpha); interleukin 
      (IL)-6, and IL-10; monocyte chemoattractant protein-1 (MCP-1); and RANTES 
      (regulated upon activation, normal T-cell expressed and secreted) genes were 
      determined using DNA polymerase chain reaction technology in 268 healthy 
      volunteers, 345 kidney transplant recipients (1997 to 1999), and 298 cadaveric 
      donors. Patients were followed up for 4 to 6 years. The distribution of alleles 
      of selected genes was identical in control subjects, cadaveric donors, and 
      recipients. Low TGF-beta production in both the donor and recipient genotypes was 
      associated with risk for early rejection (6 months) and worse graft function at 4 
      years. The only tendency for worse graft outcome was observed among 
      donor-recipient combinations mismatched for TGF-beta genotype. Genetic 
      determination of TNF-alpha and IL-10 production was associated with delayed graft 
      function and rejection. IL-6 gene polymorphisms had no effect on the incidence of 
      early acute rejections, but was associated with worse 5-year outcomes. 
      Determinations of MCP-1 overproduction and RANTES-109 TT allele were associated 
      with significant deterioration of graft function. Our data support the hypothesis 
      that the strength of the alloimmune response after transplantation is in part 
      genetically determined. Donor-recipient matching of cytokine gene polymorphisms 
      has a marginal effect.
FAU - Lacha, J
AU  - Lacha J
AD  - Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, 
      Czech Republic.
FAU - Hribova, P
AU  - Hribova P
FAU - Kotsch, K
AU  - Kotsch K
FAU - Brabcova, I
AU  - Brabcova I
FAU - Bartosova, K
AU  - Bartosova K
FAU - Volk, H-D
AU  - Volk HD
FAU - Vitko, S
AU  - Vitko S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Chemokines/*genetics
MH  - Cytokines/*genetics
MH  - Follow-Up Studies
MH  - Gene Expression Regulation/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/*immunology/pathology
MH  - *Polymorphism, Genetic
MH  - Time Factors
MH  - Tissue Donors
MH  - Treatment Outcome
EDAT- 2005/04/26 09:00
MHDA- 2005/09/27 09:00
CRDT- 2005/04/26 09:00
PHST- 2005/04/26 09:00 [pubmed]
PHST- 2005/09/27 09:00 [medline]
PHST- 2005/04/26 09:00 [entrez]
AID - S0041-1345(04)01682-3 [pii]
AID - 10.1016/j.transproceed.2004.12.224 [doi]
PST - ppublish
SO  - Transplant Proc. 2005 Mar;37(2):764-6. doi: 10.1016/j.transproceed.2004.12.224.