PMID- 15849063
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20191109
IS  - 1354-750X (Print)
IS  - 1354-750X (Linking)
VI  - 9
IP  - 6
DP  - 2004 Nov-Dec
TI  - Chromosome aberration and lipid peroxidation in chromium-exposed workers.
PG  - 418-34
AB  - Chromosome aberration frequency and lipid peroxidation levels were analyzed to 
      investigate their efficacy as biological markers for monitoring the genotoxicity 
      and oxidative damage in Korean chromium (Cr)-exposed workers. Fifty-one 
      Cr-exposed workers and 31 age-matched controls in ten chrome-plating plants were 
      sampled. The Cr level was measured in the workers' blood and urine, and in the 
      ambient air at the workplaces. The conventional Giemsa staining method and 
      fluorescence in situ hybridization (FISH) technique were used for chromosome 
      aberration analysis. Spectrum green whole chromosome paint specific for 
      chromosome 4 was used in the FISH procedure. As for lipid peroxidation, 
      malondialdehyde (MDA) was measured in the blood plasma as thiobarbituric 
      acid-reactive substances (TBARS). The blood Cr concentration was statistically 
      correlated with both the frequency of chromatid exchange and the total frequency 
      of chromosome/chromatid breaks and exchanges, as detected by the Giemsa staining. 
      Meanwhile, the frequency of translocation, as detected by the FISH technique, was 
      significantly higher in the Cr-exposed workers than in the controls and it 
      correlated with the blood Cr concentration. Although the concentration of MDA, 
      the metabolite of lipid peroxidation, in the exposed workers was higher than that 
      of the controls, no statistically significant correlation between the MDA level 
      and the blood or urine Cr levels was observed. Accordingly, the genotoxicity and 
      oxidative damage (plasma lipid peroxidation) in the Korean Cr-exposed workers 
      were consequential at quite low exposure levels, plus chromosome rearrangement, 
      especially translocation, was clearly evident as a biological response marker for 
      Cr exposure based on a significant positive correlation between the 
      translocations detected by FISH and the Cr in the blood.
FAU - Maeng, S H
AU  - Maeng SH
AD  - Center for Occupational Toxicology, Occupational Safety & Health Research 
      Institute, Korea Occupational Safety & Health Agency, 104-8 Munji-dong, 
      Yuseong-gu, Daejeon 305-380, Korea.
FAU - Chung, H W
AU  - Chung HW
FAU - Kim, K J
AU  - Kim KJ
FAU - Lee, B M
AU  - Lee BM
FAU - Shin, Y C
AU  - Shin YC
FAU - Kim, S J
AU  - Kim SJ
FAU - Yu, I J
AU  - Yu IJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Azure Stains)
RN  - 0 (Biomarkers)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0R0008Q3JB (Chromium)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Adult
MH  - Air Pollutants, Occupational
MH  - Azure Stains
MH  - *Biomarkers
MH  - Case-Control Studies
MH  - Chromium/*blood/*toxicity/urine
MH  - *Chromosome Aberrations
MH  - Chromosome Painting
MH  - Chromosomes/ultrastructure
MH  - Chromosomes, Human, Pair 4/ultrastructure
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Korea
MH  - *Lipid Peroxidation
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Middle Aged
MH  - Occupational Exposure
MH  - Smoking
MH  - Thiobarbituric Acid Reactive Substances
MH  - Time Factors
EDAT- 2005/04/26 09:00
MHDA- 2005/06/29 09:00
CRDT- 2005/04/26 09:00
PHST- 2005/04/26 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2005/04/26 09:00 [entrez]
AID - VMCET5UUKEN3PJ72 [pii]
AID - 10.1080/13547500400022200 [doi]
PST - ppublish
SO  - Biomarkers. 2004 Nov-Dec;9(6):418-34. doi: 10.1080/13547500400022200.