PMID- 15849384
OWN - NLM
STAT- MEDLINE
DCOM- 20050621
LR  - 20200106
IS  - 1734-1140 (Print)
IS  - 1734-1140 (Linking)
VI  - 57
IP  - 1
DP  - 2005 Jan-Feb
TI  - Effect of kaempferol on the production and gene expression of monocyte 
      chemoattractant protein-1 in J774.2 macrophages.
PG  - 107-12
AB  - Monocyte chemoattractant protein-1 (MCP-1) is produced by activated macrophages, 
      and is involved in pathogenesis of cardiovascular and neurodegenerative 
      disorders. There is a need to develop drugs that inhibit excessive infiltration 
      of monocytes and lymphocytes to the arterial wall and central nervous system. The 
      aim of this study was to evaluate the effect of kaempferol on the (MCP-1) gene 
      expression and MCP-1 protein release by J774.2 macrophage cultures in vitro. 
      Kaempferol given both before and after lipopolysaccharide (LPS) administration 
      reduced secretion of MCP-1. Kaempferol administered before LPS stimulation 
      significantly decreased the number of copies of MCP-1 mRNA. The results suggest 
      that kaempferol inhibits MCP-1 production at the transcriptional level, and that 
      this is an additional anti-inflammatory mechanism of action of this flavonoid.
FAU - Kowalski, Jan
AU  - Kowalski J
AD  - Department of Genomics, Medical University of Silesia, Warszawska 14, PL 40-006 
      Katowice, Poland. genomika@slam.katowice.pl
FAU - Samojedny, Arkadiusz
AU  - Samojedny A
FAU - Paul, Monika
AU  - Paul M
FAU - Pietsz, Grazyna
AU  - Pietsz G
FAU - Wilczok, Tadeusz
AU  - Wilczok T
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Chemokine CCL2)
RN  - 0 (Kaempferols)
RN  - 0 (Lipopolysaccharides)
RN  - 731P2LE49E (kaempferol)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Chemokine CCL2/*drug effects/genetics/metabolism
MH  - Gene Expression Regulation/*drug effects
MH  - Kaempferols/*pharmacology
MH  - Lipopolysaccharides/antagonists & inhibitors
MH  - Macrophages/drug effects/metabolism
MH  - Mice
EDAT- 2005/04/26 09:00
MHDA- 2005/06/23 09:00
CRDT- 2005/04/26 09:00
PHST- 2004/09/08 00:00 [received]
PHST- 2004/12/14 00:00 [revised]
PHST- 2005/04/26 09:00 [pubmed]
PHST- 2005/06/23 09:00 [medline]
PHST- 2005/04/26 09:00 [entrez]
PST - ppublish
SO  - Pharmacol Rep. 2005 Jan-Feb;57(1):107-12.