PMID- 15850451
OWN - NLM
STAT- MEDLINE
DCOM- 20051011
LR  - 20161020
IS  - 0248-4900 (Print)
IS  - 0248-4900 (Linking)
VI  - 97
IP  - 7
DP  - 2005 Jul
TI  - Heat-shock response down-regulates interleukin-18 expression in murine peritoneal 
      macrophages.
PG  - 551-6
AB  - BACKGROUND INFORMATION: The heat-shock response is a self-defence mechanism that 
      protects cells and organisms from a wide range of harmful stresses. Recent 
      studies revealed that it involved the regulation of cytokine expression. 
      Interleukin-18 (IL-18) is an important cytokine in mediating immune response. 
      RESULTS: We studied interferon-gamma (IFN-gamma)-induced IL-18 expression in 
      heat-shock-treated murine peritoneal macrophages. Our results showed that the 
      heat-shock response significantly inhibited the expression of IFN-gamma-induced 
      pro-inflammatory cytokine IL-18. Interferon consensus sequence binding protein 
      (ICSBP) is a transcription factor that binds to the promoter of IL-18 and 
      regulates the transcription of IL-18. Further research on the down-regulation 
      mechanism showed that the DNA-binding activity of ICSBP was greatly reduced by 
      the heat shock response. CONCLUSIONS: These results suggest that the inhibitory 
      effect of heat-shock response on IL-18 production in IFN-gamma-stimulated 
      macrophages is related to the suppression of the binding activity of ICSBP.
FAU - Wang, Yun
AU  - Wang Y
AD  - Institute of Burn Research, Southwest Hospital, Third Military Medical 
      University, Chongqing, 400038, People's Republic of China. yunyunwy@hotmail.com
FAU - Chang, Zongliang
AU  - Chang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biol Cell
JT  - Biology of the cell
JID - 8108529
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (Interleukin-18)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (interferon regulatory factor-8)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/metabolism
MH  - Down-Regulation
MH  - *Heat-Shock Response
MH  - Interferon Regulatory Factors
MH  - Interferon-gamma/pharmacology
MH  - Interleukin-18/genetics/*metabolism
MH  - Macrophages, Peritoneal/*metabolism
MH  - Repressor Proteins/metabolism
MH  - Transcription Factors/metabolism
EDAT- 2005/04/27 09:00
MHDA- 2005/10/12 09:00
CRDT- 2005/04/27 09:00
PHST- 2005/04/27 09:00 [pubmed]
PHST- 2005/10/12 09:00 [medline]
PHST- 2005/04/27 09:00 [entrez]
AID - BC20040108 [pii]
AID - 10.1042/BC20040108 [doi]
PST - ppublish
SO  - Biol Cell. 2005 Jul;97(7):551-6. doi: 10.1042/BC20040108.