PMID- 15852431
OWN - NLM
STAT- MEDLINE
DCOM- 20060504
LR  - 20181201
IS  - 1545-5009 (Print)
IS  - 1545-5009 (Linking)
VI  - 46
IP  - 5
DP  - 2006 May 1
TI  - ALK-positive diffuse large B-cell lymphoma.
PG  - 649-53
AB  - Anaplastic lymphoma kinase (ALK) positive diffuse large B-cell lymphoma (DLBCL) 
      is a rare subtype of non-Hodgkins lymphoma. Five such cases have been described 
      in children. We present a 9-year-old boy, in whom diagnosis of DLBCL has been 
      established in addition to congenital multiple enchondromatosis. 
      Immunohistopathological evaluation of tumor biopsy established the final 
      diagnosis of ALK + DLBCL. The clathrin gene (CLTC)-ALK fusion underlying aberrant 
      expression of ALK in the present case was demonstrated by interphase fluorescence 
      in situ hybridization (FISH) using break-apart rearrangement probes for ALK and 
      CLTC. The disease in this patient was highly resistant to applied chemotherapy 
      regimens and to radiotherapy. Analysis of the disease course in our patient and 
      review of other cases reported previously show that ALK + DLBCL can be an 
      aggressive malignancy that can be cured with conventional chemotherapy protocols 
      only at stage of localized disease.
FAU - Bubala, Halina
AU  - Bubala H
AD  - Department of Pediatric Hematology and Oncology, Silesian Medical Academy, 
      Zabrze, Poland.
FAU - Maldyk, Jadwiga
AU  - Maldyk J
FAU - Wlodarska, Iwona
AU  - Wlodarska I
FAU - Sonta-Jakimczyk, Danuta
AU  - Sonta-Jakimczyk D
FAU - Szczepanski, Tomasz
AU  - Szczepanski T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Anaplastic Lymphoma Kinase
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & dosage
MH  - Child
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/drug therapy/enzymology/*pathology
MH  - Lymphoma, Large B-Cell, Diffuse/drug therapy/enzymology/*pathology
MH  - Male
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - Receptor Protein-Tyrosine Kinases
EDAT- 2005/04/27 09:00
MHDA- 2006/05/05 09:00
CRDT- 2005/04/27 09:00
PHST- 2005/04/27 09:00 [pubmed]
PHST- 2006/05/05 09:00 [medline]
PHST- 2005/04/27 09:00 [entrez]
AID - 10.1002/pbc.20396 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2006 May 1;46(5):649-53. doi: 10.1002/pbc.20396.