PMID- 15852498
OWN - NLM
STAT- MEDLINE
DCOM- 20050811
LR  - 20050609
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 206
IP  - 3
DP  - 2005 Jul
TI  - Adenomas and follicular carcinomas of the thyroid display two major patterns of 
      chromosomal changes.
PG  - 305-11
AB  - It was recently shown by flow and static cytometry that a large sub-group of 
      follicular adenomas of the thyroid--fetal/embryonal adenomas--display an 
      aneuploid phenotype. It was also shown that thyroid lesions with a DNA content 
      within the triploid range were either fetal adenomas or follicular carcinomas 
      with a fetal adenoma growth pattern. Follicular tumours with growth patterns 
      other than the so-called fetal adenoma-like pattern were usually diploid or 
      near-diploid. In an attempt to clarify the pattern of chromosomal imbalances in 
      follicular tumours, comparative genomic hybridization (CGH) analysis was 
      performed in a series of 18 follicular neoplasms (ten fetal/embryonal and four 
      common follicular adenomas and four minimally invasive follicular carcinomas). 
      For each tumour, the DNA content was determined by flow cytometry and, in some 
      cases, also by static cytometry. Finally, the copy number of selected chromosomes 
      was determined by interphase fluorescence in situ hybridization (FISH) using 
      centromere probes. With the exception of the single diploid fetal adenoma, all 
      fetal adenomas displayed several DNA copy number changes, with frequent gains of 
      several chromosomes, which were found to be either tetrasomic or trisomic by 
      FISH. This genetic pattern was also present in the single case of follicular 
      carcinoma with aneuploidy and fetal adenoma-like growth pattern. Follicular 
      adenomas other than fetal adenomas, and the remaining follicular carcinomas, 
      showed more losses than gains of chromosomes. These results suggest that 
      follicular tumourigenesis may follow at least two pathways: one characterized by 
      prominent aneuploidy and numerous gains, in which the tumours display a fetal 
      adenoma-like growth pattern; and another accompanied by less obvious aneuploidy 
      or even quasi-diploidy and dominant chromosome losses, in which the tumours 
      display a common follicular architecture.
CI  - Copyright 2005 Pathological Society of Great Britain and Ireland. Published by 
      John Wiley & Sons, Ltd.
FAU - Castro, Patricia
AU  - Castro P
AD  - Institute of Molecular Pathology and Immunology of the University of Porto 
      (IPATIMUP), Porto, Portugal.
FAU - Eknaes, Mette
AU  - Eknaes M
FAU - Teixeira, Manuel R
AU  - Teixeira MR
FAU - Danielsen, Havard E
AU  - Danielsen HE
FAU - Soares, Paula
AU  - Soares P
FAU - Lothe, Ragnhild A
AU  - Lothe RA
FAU - Sobrinho-Simoes, Manuel
AU  - Sobrinho-Simoes M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adenoma/*genetics/pathology
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - DNA, Neoplasm/genetics
MH  - Diploidy
MH  - Fetal Diseases/genetics/pathology
MH  - Flow Cytometry/methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Neoplasm Invasiveness
MH  - Nucleic Acid Hybridization/methods
MH  - Thyroid Gland/pathology
MH  - Thyroid Neoplasms/*genetics/pathology
EDAT- 2005/04/27 09:00
MHDA- 2005/08/12 09:00
CRDT- 2005/04/27 09:00
PHST- 2005/04/27 09:00 [pubmed]
PHST- 2005/08/12 09:00 [medline]
PHST- 2005/04/27 09:00 [entrez]
AID - 10.1002/path.1772 [doi]
PST - ppublish
SO  - J Pathol. 2005 Jul;206(3):305-11. doi: 10.1002/path.1772.