PMID- 15853731
OWN - NLM
STAT- MEDLINE
DCOM- 20050630
LR  - 20191109
IS  - 1566-5232 (Print)
IS  - 1566-5232 (Linking)
VI  - 5
IP  - 2
DP  - 2005 Apr
TI  - Adenovirus-mediated transgene-engineered dendritic cell vaccine of cancer.
PG  - 237-47
AB  - Dendritic cells (DCs) are the most effective antigen presenting cells (APCs) to 
      elicit both primary and secondary T-cell response that is critical for antitumor 
      immunity and elimination of intracellular pathogens. Therefore, DCs pulsed ex 
      vivo with antigens have the potential used as cell-based vaccines against tumors. 
      Viral vectors derived from adenoviruses have been extensively used to pulse DCs 
      ex vivo by delivering genes encoding immunomodulatory molecules and tumor 
      antigens to DCs since these vectors are relatively safe, effective in inducing 
      the maturation of DCs, and can accommodate large expression cassettes encoding 
      antigens. One of the hurdles for gene delivery to DCs by adenovirus (Ad) vectors, 
      however, is low transfection efficiency of DCs due to the paucity of Ad receptor 
      on DCs. To overcome this obstacle, targeted Ad vectors have been made by 
      modifying viral capsid proteins. These targeted Ad vectors not only enhance the 
      gene delivery to DCs, but also allow in vivo gene delivery to DCs, thus avoiding 
      ex vivo manipulation of DCs.
FAU - Wu, Qiaohua
AU  - Wu Q
AD  - Defense Research and Development of Canada Suffield, Alberta, Canada.
FAU - Xia, Dajing
AU  - Xia D
FAU - Carlsen, Svein
AU  - Carlsen S
FAU - Xiang, Jim
AU  - Xiang J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Gene Ther
JT  - Current gene therapy
JID - 101125446
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Adenoviridae/*genetics
MH  - Animals
MH  - Cancer Vaccines/*therapeutic use
MH  - Dendritic Cells/*immunology
MH  - Genetic Engineering
MH  - Humans
MH  - Neoplasms/*therapy
MH  - Transgenes/*genetics
RF  - 124
EDAT- 2005/04/28 09:00
MHDA- 2005/07/01 09:00
CRDT- 2005/04/28 09:00
PHST- 2005/04/28 09:00 [pubmed]
PHST- 2005/07/01 09:00 [medline]
PHST- 2005/04/28 09:00 [entrez]
AID - 10.2174/1566523053544272 [doi]
PST - ppublish
SO  - Curr Gene Ther. 2005 Apr;5(2):237-47. doi: 10.2174/1566523053544272.