PMID- 15853900
OWN - NLM
STAT- MEDLINE
DCOM- 20050919
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 65
IP  - 5
DP  - 2005 May
TI  - HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational 
      allergic cough to Bunashimeji mushroom.
PG  - 459-66
AB  - We previously reported that two-third of workers in a Bunashimeji mushroom 
      (Hypsizigus marmoreus) farm complained of respiratory allergic symptoms, but 
      one-third workers did not suffer from such symptoms even when working for a long 
      period. CD4+ T-helper (Th) cells increased, and Th2/Th1 ratio increased in the 
      allergic workers. To address these immunological backgrounds, we have 
      investigated whether there is any relationship between mushroom allergy and human 
      leukocyte antigen (HLA) class II alleles of DPB1, DQA1, DQB1, and DRB1 by using 
      the polymerase chain reaction-restriction fragment length polymorphism (RFLP) and 
      sequencing-based typing methods. We observed that the allele frequencies of 
      DQA1*0103, DQB1*0601, and DRB1*0803 were significantly higher in the workers 
      having no allergic symptoms than allergic workers (DQA1*0103: 57 vs 25%, 
      DQB1*0601: 49 vs 14%, and DRB1*0803: 29 vs 0%). However, this phenomenon was not 
      seen in workers producing another kind of mushroom, Honshimeji (Lyophyllum 
      aggregatum). The HLA-DRB1*0803 allele alone, the DRB1*0803, DQA1*0103, DQB1*0601 
      haplotype, or both were negatively associated with allergy to Bunashimeji, and 
      these alleles might be involved in the prevention of Bunashimeji 
      mushroom-specific respiratory allergy.
FAU - Suzuki, K
AU  - Suzuki K
AD  - Third Department of Internal Medicine, Sapporo Medical University School of 
      Medicine, Hokkaido, Japan. k-suzuki@hospital.hakodate.hokkaido.jp
FAU - Tanaka, H
AU  - Tanaka H
FAU - Sahara, H
AU  - Sahara H
FAU - Tanaka, N
AU  - Tanaka N
FAU - Tamura, Y
AU  - Tamura Y
FAU - Naruse, T
AU  - Naruse T
FAU - Inoko, H
AU  - Inoko H
FAU - Tsushima, K
AU  - Tsushima K
FAU - Kubo, K
AU  - Kubo K
FAU - Abe, S
AU  - Abe S
FAU - Sato, N
AU  - Sato N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - *Agaricales/immunology
MH  - Agricultural Workers' Diseases/epidemiology/*genetics/immunology
MH  - Alleles
MH  - Cough/epidemiology/etiology/*genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-D Antigens/*genetics/immunology
MH  - HLA-DP Antigens/genetics/immunology
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Respiratory Hypersensitivity/epidemiology/etiology/*genetics/immunology
MH  - Species Specificity
EDAT- 2005/04/28 09:00
MHDA- 2005/09/20 09:00
CRDT- 2005/04/28 09:00
PHST- 2005/04/28 09:00 [pubmed]
PHST- 2005/09/20 09:00 [medline]
PHST- 2005/04/28 09:00 [entrez]
AID - TAN402 [pii]
AID - 10.1111/j.1399-0039.2005.00402.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 May;65(5):459-66. doi: 10.1111/j.1399-0039.2005.00402.x.