PMID- 15853982
OWN - NLM
STAT- MEDLINE
DCOM- 20050908
LR  - 20220318
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 20
IP  - 5
DP  - 2005 May
TI  - Risk of colorectal cancer in ulcerative colitis in India.
PG  - 705-9
AB  - BACKGROUND: The risk for colorectal cancer (CRC) in ulcerative colitis (UC) in 
      India is not known. METHOD: Retrospective cohort from a tertiary level hospital 
      in South India. Analysis of archived records of all patients with UC who 
      underwent colonoscopy and segmental biopsies over the last 25 years. Incidence 
      densities and risk of developing high grade dysplasia or CRC was calculated and 
      chi-squared test was performed for risk factors of interest. RESULTS: Complete 
      records were available for 532 patients, 336 (63.2%) male. The mean (+/- SEM) 
      duration of illness was 6.04 +/- 0.29 years. In total, 234 patients (44%) had 
      pancolitis, 121 (22.7%) had left-sided colitis and 177 (33.3%) had proctitis or 
      proctosigmoiditis. Overall, five (0.94%) patients developed carcinoma and one 
      (0.19%) patient had high grade dysplasia. The incidence density and risk of 
      developing either CRC or high grade dysplasia was zero in the first 10 years of 
      disease. In those with disease duration of 10-20 years, incidence density was 
      2.34 per 1000 person years' duration (PYD) for all patients with colitis and 4.5 
      per 1000 PYD for patients with pancolitis alone. This corresponded to risks of 
      2.3% and 4.4%, respectively. For those with disease duration longer than 20 
      years, incidence density was 2.73 per 1000 PYD for all patients and 4.9 per 1000 
      PYD for patients with pancolitis. This corresponded to risks of 5.8% and 10.2%, 
      respectively. Duration of disease beyond 10 years and extent of colitis were the 
      only risk factors significantly associated with CRC. CONCLUSIONS: The risk of 
      developing CRC is Indian patients with UC is lower than that reported from the 
      West. Strategies for cancer surveillance in Indian patients with UC need to be 
      tailored accordingly.
FAU - Venkataraman, Subramanian
AU  - Venkataraman S
AD  - Department of Gastrointestinal Sciences, Christian Medical College, Vellore, 
      India.
FAU - Mohan, Vivek
AU  - Mohan V
FAU - Ramakrishna, Balakrishnan S
AU  - Ramakrishna BS
FAU - Peter, Shajan
AU  - Peter S
FAU - Chacko, Ashok
AU  - Chacko A
FAU - Chandy, George
AU  - Chandy G
FAU - Kurian, George
AU  - Kurian G
FAU - Kurian, Susy
AU  - Kurian S
FAU - Mathan, Minnie
AU  - Mathan M
FAU - Mathan, Vadakkenadayil I
AU  - Mathan VI
FAU - Patra, Susama
AU  - Patra S
FAU - Pulimood, Anna
AU  - Pulimood A
FAU - Rolston, David Dk
AU  - Rolston DD
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Colitis, Ulcerative/*complications/pathology
MH  - Colorectal Neoplasms/epidemiology/*etiology/pathology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - India
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2005/04/28 09:00
MHDA- 2005/09/09 09:00
CRDT- 2005/04/28 09:00
PHST- 2005/04/28 09:00 [pubmed]
PHST- 2005/09/09 09:00 [medline]
PHST- 2005/04/28 09:00 [entrez]
AID - JGH3810 [pii]
AID - 10.1111/j.1440-1746.2005.03810.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2005 May;20(5):705-9. doi: 
      10.1111/j.1440-1746.2005.03810.x.