PMID- 15854140
OWN - NLM
STAT- MEDLINE
DCOM- 20060117
LR  - 20191210
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 32
IP  - 5-6
DP  - 2005 May-Jun
TI  - Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly 
      inactivating virus infectivity.
PG  - 346-9
AB  - 1. The ethyl acetate (EtOAc) extract and 
      3-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-d-glucose (3OG46HG) of Euphorbia 
      thymifolia Linnea have been shown to exhibit anti-herpes simplex virus (HSV)-2 
      activity in vitro. In the present study, we investigated the mode of action of 
      these two compounds in suppressing HSV-2 multiplication. 2. The results 
      demonstrated that the EtOAc extract and 3OG46HG affected virus infectivity in a 
      dose-dependent manner. The EtOAc extract significantly reduced virus infectivity 
      at a concentration of 4.0 microg/mL, whereas 3OG46HG obviously diminished virus 
      infectivity at concentration of a 0.5 microg/mL. The virucidal ability of the 
      EtOAc extract was affected by the incubation period, but not by the incubation 
      temperature. In the case of the action of 3OG46HG against HSV-2, the effects of 
      incubation time and temperature were negligible. 3. In summary, the EtOAc extract 
      and 3OG46HG of E. thymifolia are concluded to inhibit HSV-2 multiplication by 
      reducing virus infectivity.
FAU - Yang, Chien-Min
AU  - Yang CM
AD  - Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
FAU - Cheng, Hua-Yew
AU  - Cheng HY
FAU - Lin, Ta-Chen
AU  - Lin TC
FAU - Chiang, Lien-Chai
AU  - Chiang LC
FAU - Lin, Chun-Ching
AU  - Lin CC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Antiviral Agents)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/chemistry/isolation & purification/*pharmacology/therapeutic use
MH  - Chlorocebus aethiops
MH  - Dose-Response Relationship, Drug
MH  - *Euphorbia
MH  - Herpes Simplex/*prevention & control/virology
MH  - Herpesvirus 2, Human/*drug effects/physiology
MH  - Plant Extracts/chemistry/isolation & purification/pharmacology/therapeutic use
MH  - Vero Cells
EDAT- 2005/04/28 09:00
MHDA- 2006/01/18 09:00
CRDT- 2005/04/28 09:00
PHST- 2005/04/28 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/04/28 09:00 [entrez]
AID - CEP4194 [pii]
AID - 10.1111/j.1440-1681.2005.04194.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):346-9. doi: 
      10.1111/j.1440-1681.2005.04194.x.