PMID- 15856322
OWN - NLM
STAT- MEDLINE
DCOM- 20050915
LR  - 20181113
IS  - 0931-041X (Print)
IS  - 0931-041X (Linking)
VI  - 20
IP  - 6
DP  - 2005 Jun
TI  - Association of vitamin-D and calcitonin receptor gene polymorphism in paediatric 
      nephrolithiasis.
PG  - 773-6
AB  - We investigated the role of vitamin-D receptor gene (VDR) and calcitonin receptor 
      (CTR) gene polymorphism in childhood nephrolithiasis in the north Indian 
      population. A control group of 60 healthy paediatric individuals (age range 4-16 
      years) and 50 paediatric patients (age range 2-14 years) with kidney stones were 
      examined. Polymorphism in both genes (VDR and CTR) was detected by using 
      PCR-based restriction analysis. There was a statistically significant difference 
      between the two groups for the genotypes of the VDR gene Fok-I polymorphism (P 
      =0.007) and the CTR gene (P =0.048) polymorphism. The odds ratio (95% Confidence 
      Interval) for the C allele in those at risk of stone disease was 1.83 (0.82-4.09) 
      in VDR gene polymorphism and 1.99 (0.90-4.39) in the case of CTR gene 
      polymorphism. Our results suggest that the effects of VDR (Fok-I) and CTR gene 
      polymorphism contribute to the understanding of the pathogenesis of urinary 
      calculi. It is also suggestive of a potential candidate gene in the search for 
      genetic causes of paediatric calcium oxalate nephrolithiasis.
FAU - Bid, Hemant Kumar
AU  - Bid HK
AD  - Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, 
      Lucknow, Uttar Pradesh, India.
FAU - Chaudhary, Himanshu
AU  - Chaudhary H
FAU - Mittal, Rama Devi
AU  - Mittal RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050426
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Receptors, Calcitonin)
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Confidence Intervals
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Kidney Calculi/*genetics
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Prospective Studies
MH  - Receptors, Calcitonin/*genetics
MH  - Receptors, Calcitriol/*genetics
EDAT- 2005/04/28 09:00
MHDA- 2005/09/16 09:00
CRDT- 2005/04/28 09:00
PHST- 2004/06/15 00:00 [received]
PHST- 2005/01/04 00:00 [accepted]
PHST- 2004/12/29 00:00 [revised]
PHST- 2005/04/28 09:00 [pubmed]
PHST- 2005/09/16 09:00 [medline]
PHST- 2005/04/28 09:00 [entrez]
AID - 10.1007/s00467-005-1846-4 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2005 Jun;20(6):773-6. doi: 10.1007/s00467-005-1846-4. Epub 2005 
      Apr 26.