PMID- 15857302
OWN - NLM
STAT- MEDLINE
DCOM- 20050707
LR  - 20191109
IS  - 1568-007X (Print)
IS  - 1568-007X (Linking)
VI  - 4
IP  - 2
DP  - 2005 Apr
TI  - Estrogens as protectants of the neurovascular unit against ischemic stroke.
PG  - 169-77
AB  - Estrogens are now recognized as potent neuroprotectants in a variety of in vitro 
      and in vivo model for cerebral ischemia. These protective effects of estrogens 
      are seen in neurons, astrocytes, microglia and vascular endothelial cells and 
      result in a profound protection of the brain during stroke. Herein, we provide a 
      thesis that indicates that the protective effects of estrogens during stroke may 
      be a combined effect on multiple targets of the neurovascular unit (NVU) through 
      a fundamental protective effect of estrogens on the subcellular organelle that 
      defines the fate of cells during insults, the mitochondria. By protecting 
      mitochondria during insult, estrogens are able to reduce or eliminate the signal 
      for cellular necrosis or apoptosis and thereby protect the NVU from 
      ischemia/reperfusion. In this context, estrogens may be unique in their ability 
      to target the cellular site of initiation of damage during stroke and could be a 
      central compound in a multi-drug approach to the prevention and treatment of 
      brain damage from stroke.
FAU - Yang, Shao-Hua
AU  - Yang SH
AD  - Department of Pharmacology and Neuroscience, Health Science Center, University of 
      North Texas, Fort Worth, TX. 76123, USA.
FAU - Liu, Ran
AU  - Liu R
FAU - Perez, Evelyn J
AU  - Perez EJ
FAU - Wang, Xiaofei
AU  - Wang X
FAU - Simpkins, James W
AU  - Simpkins JW
LA  - eng
GR  - AG 22550/AG/NIA NIH HHS/United States
GR  - AG10485/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - Curr Drug Targets CNS Neurol Disord
JT  - Current drug targets. CNS and neurological disorders
JID - 101151150
RN  - 0 (Estrogens)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Brain/blood supply/cytology/metabolism
MH  - Brain Ischemia/complications/*metabolism/prevention & control
MH  - Cerebral Arteries/cytology
MH  - Endothelium, Vascular/metabolism
MH  - Estrogens/*metabolism/therapeutic use
MH  - Humans
MH  - Microglia/metabolism
MH  - Mitochondria/*metabolism
MH  - Muscle, Smooth, Vascular/metabolism
MH  - Neurons/metabolism
MH  - Neuroprotective Agents/*metabolism/therapeutic use
MH  - Reperfusion Injury/drug therapy/metabolism/prevention & control
MH  - Stroke/complications/drug therapy/*metabolism
RF  - 119
EDAT- 2005/04/29 09:00
MHDA- 2005/07/08 09:00
CRDT- 2005/04/29 09:00
PHST- 2005/04/29 09:00 [pubmed]
PHST- 2005/07/08 09:00 [medline]
PHST- 2005/04/29 09:00 [entrez]
AID - 10.2174/1568007053544174 [doi]
PST - ppublish
SO  - Curr Drug Targets CNS Neurol Disord. 2005 Apr;4(2):169-77. doi: 
      10.2174/1568007053544174.