PMID- 15859024
OWN - NLM
STAT- MEDLINE
DCOM- 20050817
LR  - 20061115
IS  - 0036-5513 (Print)
IS  - 0036-5513 (Linking)
VI  - 65
IP  - 1
DP  - 2005
TI  - Serum C-reactive protein in elderly men and women: association with mortality, 
      morbidity and various biochemical values.
PG  - 23-31
AB  - OBJECTIVE: The primary aim of this study was to define the distribution and the 
      prognostic value of serum C-reactive protein (s-CRP) measured by a 
      high-sensitivity method in elderly subjects of both genders with special 
      reference to the distribution below 10 mg/l. As a secondary aim, a possible 
      gender difference of s-CRP was examined. MATERIAL AND METHODS: Baseline s-CRP was 
      described in a population-based sample of opposite-sex, twin-pairs (197 F, 189 M 
      available for blood-sampling) aged 71-80 years (mean age 74.5 years), considering 
      mortality through the next 4 years, morbidity (myocardial infarction, angina 
      pectoris, congestive heart failure, arterial hypertension, venous 
      thromboembolism, stroke, diabetes, gout, psoriasis, rheumatoid arthritis) before 
      and after blood sampling, biochemical values (serum levels of urate, urea, ApoA1, 
      ApoB, folate, FSH, LH, oestradiol, progesterone, testosterone, cortisol) and 
      anthropometric measurements (body mass index (BMI), circumference of waist, 
      buttocks and hips). RESULTS: The level of s-CRP did not deviate substantially 
      from what has been reported for younger subjects. Higher values indicated an 
      increased risk of cardiovascular morbidity and diabetes in women but not in men. 
      The s-CRP level was associated with serum levels of urate, progesterone, folate, 
      ApoA1, ApoB and the quotient ApoB/ApoA1 as well as with BMI and waist 
      circumference. CONCLUSIONS: For the 71-80 years age group, s-CRP below the 80th 
      percentile (4.3 mg/l) seems to have prognostic capacity mainly in women. The 
      highest association with mortality as well as with cardiovascular diseases, 
      diabetes and rheumatoid arthritis is found for s-CRP above 10 mg/l, which is the 
      arbitrary lower level for the earlier routine low-sensitivity s-CRP methods. The 
      association of s-CRP with serum urate, folate and the ApoB/ApoA1 quotient should 
      be considered.
FAU - Evrin, P E
AU  - Evrin PE
AD  - Department of Clinical Chemistry, Ryhov Hospital, Jonkoping, Sweden.
FAU - Nilsson, S E
AU  - Nilsson SE
FAU - Oberg, T
AU  - Oberg T
FAU - Malmberg, B
AU  - Malmberg B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - C-Reactive Protein/analysis/*metabolism
MH  - Disease
MH  - Female
MH  - Humans
MH  - Male
MH  - *Morbidity
MH  - *Mortality
MH  - Sex Characteristics
EDAT- 2005/04/30 09:00
MHDA- 2005/08/18 09:00
CRDT- 2005/04/30 09:00
PHST- 2005/04/30 09:00 [pubmed]
PHST- 2005/08/18 09:00 [medline]
PHST- 2005/04/30 09:00 [entrez]
AID - 10.1080/00365510510013505 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2005;65(1):23-31. doi: 10.1080/00365510510013505.