PMID- 15859903
OWN - NLM
STAT- MEDLINE
DCOM- 20050620
LR  - 20050429
IS  - 1304-0855 (Print)
IS  - 1304-0855 (Linking)
VI  - 1
IP  - 1
DP  - 2003 Jun
TI  - The relationship between HLA typing and HCV infection and outcome of renal 
      transplantation in HCV positive patients.
PG  - 19-25
AB  - The role of Human Leukocytic Antigen (HLA) antigens in susceptibility to 
      Hepatitis C Virus (HCV) infection is still being debated. We analyzed HLA 
      phenotype frequencies in two major ethnic groups, namely Egyptian and Saudi 
      nationals. The Egyptian group included 110 patients of whom 55 were HCV positive 
      and the other 55 HCV negative (control group). The Saudi group included 146 HCV 
      positive patients and 122 HCV negative individuals (control group). The results 
      for the Egyptian population revealed increased frequencies of some HLA phenotypes 
      and decreased frequencies of others but without any statistically significant 
      difference. In contrast, in the Saudi population, the HLA-A19 phenotype was 
      significantly increased in HCV positive patients when compared with the control 
      group while significantly decreased frequencies were found for HLA-B8, HLA-DRI 
      and HLA DR3. Our data suggest that there was no significant association between 
      HLA phenotypes and susceptibility to HCV infection among the Egyptian population 
      while the overall data of the Saudi population seem to indicate that the 
      expression of particular HLA alleles could be associated with susceptibility or 
      resistance to the HCV infection. Further studies on larger numbers of patients 
      are needed to support the role of the HLA system in HCV infection. A total of 108 
      HCV positive patients underwent renal transplantation at the Jeddah Kidney Center 
      and the results were compared with 100 age and sex-matched controls. Graft 
      survival at 36 months was 82% and 86% for HCV positive and control subjects 
      respectively while patient survival was respectively 90% and 91%. Our data 
      suggest that the outcome, at least in the Short-time, of renal transplantation in 
      HCV positive patients is very good.
FAU - Hadhoud, Alaa
AU  - Hadhoud A
AD  - Dept. of Microbiology, Faculty of Medicine, Zagazig University, Egypt, King 
      Abdulaziz Hospital & Oncology Center, Saudi Arabia.
FAU - Abdulaziz, Azza M
AU  - Abdulaziz AM
FAU - Menawi, Lubna Al
AU  - Menawi LA
FAU - Shaheen, F A
AU  - Shaheen FA
FAU - Abdulghaffar, Aliah
AU  - Abdulghaffar A
FAU - Abas, Fahd Al
AU  - Abas FA
FAU - Al Mobrak, Mohammed F
AU  - Al Mobrak MF
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Exp Clin Transplant
JT  - Experimental and clinical transplantation : official journal of the Middle East 
      Society for Organ Transplantation
JID - 101207333
SB  - IM
MH  - Egypt/epidemiology
MH  - Graft Survival
MH  - Hepacivirus/*isolation & purification
MH  - Hepatitis C/*complications/mortality
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Kidney Diseases/*complications/epidemiology/*surgery
MH  - *Kidney Transplantation/mortality
MH  - Phenotype
MH  - Prevalence
MH  - Saudi Arabia/epidemiology
MH  - Treatment Outcome
EDAT- 2005/04/30 09:00
MHDA- 2005/06/21 09:00
CRDT- 2005/04/30 09:00
PHST- 2005/04/30 09:00 [pubmed]
PHST- 2005/06/21 09:00 [medline]
PHST- 2005/04/30 09:00 [entrez]
PST - ppublish
SO  - Exp Clin Transplant. 2003 Jun;1(1):19-25.