PMID- 15860356
OWN - NLM
STAT- MEDLINE
DCOM- 20050609
LR  - 20221207
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 159
IP  - 1
DP  - 2005 May
TI  - Association between the stages of cervical cancer and chromosome 1 aneusomy.
PG  - 44-7
AB  - The high-risk human papillomavirus is known to play a pivotal role in cervical 
      carcinogenesis. Numerical and structural aberrations are known to be related to 
      different behaviors of malignant cervical lesions. The aims of this study were 
      (1) to assess the number of cervical cells with chromosome 1 aneusomy (monosomy, 
      trisomy, and tetrasomy) in 20 women with cervical intraepithelial neoplasia (CIN 
      1, CIN 2, CIN 3, and invasive cancer) and three women without CIN by fluorescence 
      in situ hybridization (FISH), (2) to determine the heterogeneity of aneusomy 
      among women within each of the five groups studied, (3) to determine the 
      association between the four progressive stages of cervical cancer and the number 
      of cells with and without aneusomy, (4) to determine the association between 
      number of cells with and without aneusomy and human papilloma virus (HPV) 
      infection, and (5) to determine its usefulness as a biomarker of cancer risk. A 
      hospital-based unmatched case-control study in a sample of 23 women grouped by 
      disease stage and selected by histology from the Obstetrics and Gynecology 
      Hospital of the Instituto Mexicano del Seguro Social (IMSS) in Mexico was 
      conducted in 2002. Numerical aberrations of chromosome 1 in cervical smears were 
      detected with FISH. HPV was detected with polymerase chain reaction (PCR) and 
      typing was performed with restriction fragment length polymorphism (RFLPs). 
      Analysis of chromosome 1 aneusomy revealed (1) homogeneity among women within 
      each one of the five groups, (2) a positive linear trend between the aneusomy 
      frequency and grade of lesion, and (3) an association between aneusomy and 
      high-risk HPV infection. These findings suggest the usefulness of the number of 
      cervical cells with chromosome 1 aneusomy as a biomarker. In order to validate 
      this biomarker we suggest a larger prospective study of cytological samples of 
      patients with a longer follow-up.
FAU - Cortes-Gutierrez, Elva I
AU  - Cortes-Gutierrez EI
AD  - Genetics Division, Centro de Investigacion Biomedica del Noreste, Instituto 
      Mexicano del Seguro Social, Administracion de Correos No. 4, Apartado postal 20, 
      C.P. 64720 Monterrey, Nuevo Leon, Mexico. elvacortes@cibinmty.net
FAU - Davila-Rodriguez, Martha I
AU  - Davila-Rodriguez MI
FAU - Muraira-Rodriguez, Marycarmen
AU  - Muraira-Rodriguez M
FAU - Said-Fernandez, Salvador
AU  - Said-Fernandez S
FAU - Cerda-Flores, Ricardo M
AU  - Cerda-Flores RM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cervix Uteri/metabolism/pathology
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Papillomaviridae/classification/*isolation & purification
MH  - Papillomavirus Infections/complications/virology
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/*genetics/pathology/virology
MH  - Uterine Cervical Dysplasia/*genetics/pathology/virology
EDAT- 2005/04/30 09:00
MHDA- 2005/06/10 09:00
CRDT- 2005/04/30 09:00
PHST- 2004/07/06 00:00 [received]
PHST- 2004/09/23 00:00 [revised]
PHST- 2004/10/01 00:00 [accepted]
PHST- 2005/04/30 09:00 [pubmed]
PHST- 2005/06/10 09:00 [medline]
PHST- 2005/04/30 09:00 [entrez]
AID - S0165-4608(04)00457-1 [pii]
AID - 10.1016/j.cancergencyto.2004.10.001 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 May;159(1):44-7. doi: 
      10.1016/j.cancergencyto.2004.10.001.