PMID- 15860362
OWN - NLM
STAT- MEDLINE
DCOM- 20050609
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 159
IP  - 1
DP  - 2005 May
TI  - Burkitt-type acute leukemia in a patient with B-prolymphocytic leukemia: evidence 
      for a common origin.
PG  - 74-8
AB  - Burkitt-type acute leukemia cells were present in the bone marrow of a patient 
      with B-prolymphocytic leukemia diagnosed from peripheral blood cell morphology. 
      Immunophenotype analysis confirmed morphological patterns. Cytogenetic and 
      fluorescence in situ hybridization (FISH) analysis showed an identical 
      t(8;22)(q24;q21) with MYC locus rearrangement in blood and bone marrow cells, 
      with additional chromosome abnormalities in the bone marrow. In addition, the 
      loss of one copy of the TP53 gene and identical IGH DNA clonal rearrangements 
      were shown with FISH and polymerase chain reaction analysis respectively in the 
      two types of leukemic cells. These data indicated the common origin of the two 
      coexisting leukemias and are the first example of such occurrence in a leukemic 
      patient.
FAU - Nguyen-Khac, Florence
AU  - Nguyen-Khac F
AD  - Service d'Hematologie Biologique, Groupe Hospitalier Pitie-Salpetriere, Paris, 
      France. florence.nguyen@psl.ap-hop-paris.fr
FAU - Davi, Frederic
AU  - Davi F
FAU - Receveur, Aline
AU  - Receveur A
FAU - Maloum, Karim
AU  - Maloum K
FAU - Morel, Veronique
AU  - Morel V
FAU - Le Garff-Tavernier, Magali
AU  - Le Garff-Tavernier M
FAU - Ong, Jeanne
AU  - Ong J
FAU - Berger, Roland
AU  - Berger R
FAU - Leblond, Veronique
AU  - Leblond V
FAU - Merle-Beral, Helene
AU  - Merle-Beral H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Bone Marrow/pathology
MH  - Burkitt Lymphoma/*genetics/pathology
MH  - Cell Lineage
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Gene Rearrangement
MH  - Genes, myc
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Prolymphocytic/*genetics/pathology
MH  - Middle Aged
MH  - Neoplasms, Second Primary/*genetics/pathology
MH  - *Translocation, Genetic
EDAT- 2005/04/30 09:00
MHDA- 2005/06/10 09:00
CRDT- 2005/04/30 09:00
PHST- 2004/07/22 00:00 [received]
PHST- 2004/09/16 00:00 [revised]
PHST- 2004/09/29 00:00 [accepted]
PHST- 2005/04/30 09:00 [pubmed]
PHST- 2005/06/10 09:00 [medline]
PHST- 2005/04/30 09:00 [entrez]
AID - S0165-4608(04)00458-3 [pii]
AID - 10.1016/j.cancergencyto.2004.09.016 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 May;159(1):74-8. doi: 
      10.1016/j.cancergencyto.2004.09.016.