PMID- 15860497
OWN - NLM
STAT- MEDLINE
DCOM- 20051017
LR  - 20151119
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 20
IP  - 7
DP  - 2005 Jul
TI  - Exposure to persistent organochlorine pollutants associates with human sperm Y:X 
      chromosome ratio.
PG  - 1903-9
AB  - BACKGROUND: During the last decades, there has been concern that exposure to 
      endocrine disruptors, such as persistent organochlorine pollutants (POPs), may 
      contribute to sex ratio changes in offspring of exposed populations. METHODS: To 
      investigate whether exposure to 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and 
      dichlorodiphenyl dichloroethene (p,p'-DDE) affect Y:X chromosome proportion, 
      semen of 149 Swedish fishermen, aged 27-67 years, was investigated. The men 
      provided semen and blood for analysis of hormone, CB-153 and p,p'-DDE levels. The 
      proportion of Y- and X-chromosome bearing sperm in semen samples was determined 
      by two-colour fluorescence in situ hybridization (FISH) analysis. RESULTS: Log 
      transformed CB-153 as well as log transformed p,p'-DDE variables were both 
      significantly positively associated with Y chromosome fractions (P-values = 0.05 
      and <0.001, respectively). Neither age, smoking nor hormone levels showed any 
      association with Y-chromosome fractions. CONCLUSIONS: This is the first study to 
      indicate that exposure to POPs may increase the proportion of ejaculated 
      Y-bearing spermatozoa. These data add to the growing body of evidence that 
      exposure to POPs may alter the offspring sex ratio.
FAU - Tiido, Tarmo
AU  - Tiido T
AD  - Fertility Centre, Scanian Andrology Centre, Malmo University Hospital, Lund 
      University, SE 205 02 Malmo, Sweden. Tarmo.Tiido@kir.mas.lu.se
FAU - Rignell-Hydbom, Anna
AU  - Rignell-Hydbom A
FAU - Jonsson, Bo
AU  - Jonsson B
FAU - Giwercman, Yvonne Lundberg
AU  - Giwercman YL
FAU - Rylander, Lars
AU  - Rylander L
FAU - Hagmar, Lars
AU  - Hagmar L
FAU - Giwercman, Aleksander
AU  - Giwercman A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050428
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Chromosomes, Human, X/*drug effects
MH  - Chromosomes, Human, Y/*drug effects
MH  - Dichlorodiphenyl Dichloroethylene/blood/toxicity
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Fishes
MH  - Food Contamination
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood/*toxicity
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/blood/toxicity
MH  - Sex Ratio
MH  - Spermatozoa/*drug effects/*ultrastructure
MH  - Sweden
EDAT- 2005/04/30 09:00
MHDA- 2005/10/18 09:00
CRDT- 2005/04/30 09:00
PHST- 2005/04/30 09:00 [pubmed]
PHST- 2005/10/18 09:00 [medline]
PHST- 2005/04/30 09:00 [entrez]
AID - deh855 [pii]
AID - 10.1093/humrep/deh855 [doi]
PST - ppublish
SO  - Hum Reprod. 2005 Jul;20(7):1903-9. doi: 10.1093/humrep/deh855. Epub 2005 Apr 28.