PMID- 1586053
OWN - NLM
STAT- MEDLINE
DCOM- 19920612
LR  - 20231213
IS  - 0003-0805 (Print)
IS  - 0003-0805 (Linking)
VI  - 145
IP  - 5
DP  - 1992 May
TI  - Risk factors of soybean epidemic asthma. The role of smoking and atopy.
PG  - 1098-102
AB  - Epidemics of emergency room admissions for asthma occurring in Barcelona during 
      the period 1981 to 1987 were caused by inhalation of soybean dust. To investigate 
      the risk factors that determined why some asthma patients became reactive to 
      soybean and were consequently affected by the asthma epidemics of Barcelona but 
      others did not do so, a case-control study was conducted during 1989, 2 yr after 
      the cessation of asthma epidemics. Patients with asthma admitted in emergency 
      room services during epidemic asthma days (n = 169) were compared with asthma 
      patients admitted in the same services during nonepidemic days and who were never 
      admitted during the epidemics (n = 147). Risk factors other than soybean 
      exposure, namely skin reactivity against at least one common allergen (odds ratio 
      [OR] 3.0, 1.7 to 5.3), age over 64 yr (OR 2.8, 1.4 to 6.0), cigarette smoking at 
      the time of the epidemics (OR 2.3, 1.2 to 2.4), past smoking (OR 1.8, 0.9 to 
      3.7), and total immunoglobulin E (IgE) higher than 100 IU/ml (OR 1.7, 1.0 to 
      3.0), were found independently related to epidemic asthma. The role of smoking 
      was especially important for those who had a positive skin reaction and were 
      exposed to soybean dust (OR 7.9, 1.8 to 36.0). In this group, a dose-response 
      pattern with pack-years was observed (p less than 0.01). The present findings 
      suggest a multifactorial process for epidemic asthma, in which atopy and 
      cigarette smoking played an important synergistic role. This has a preventive 
      potential for IgE-related asthma.
FAU - Sunyer, J
AU  - Sunyer J
AD  - Departament d'Epidemiologia i Salut Publica, Institut Municipal d'Investigacio 
      Medica, Barcelona, Spain.
FAU - Anto, J M
AU  - Anto JM
FAU - Sabria, J
AU  - Sabria J
FAU - Rodrigo, M J
AU  - Rodrigo MJ
FAU - Roca, J
AU  - Roca J
FAU - Morell, F
AU  - Morell F
FAU - Rodriguez-Roisin, R
AU  - Rodriguez-Roisin R
FAU - Codina, R
AU  - Codina R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Rev Respir Dis
JT  - The American review of respiratory disease
JID - 0370523
RN  - 0 (Dust)
SB  - IM
MH  - Asthma/*epidemiology/immunology
MH  - Case-Control Studies
MH  - *Disease Outbreaks
MH  - Dust/adverse effects
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Skin Tests
MH  - Smoking/*epidemiology
MH  - Glycine max/*adverse effects
MH  - Spain/epidemiology
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.1164/ajrccm/145.5.1098 [doi]
PST - ppublish
SO  - Am Rev Respir Dis. 1992 May;145(5):1098-102. doi: 10.1164/ajrccm/145.5.1098.