PMID- 15860984
OWN - NLM
STAT- MEDLINE
DCOM- 20050609
LR  - 20191109
IS  - 1520-037X (Print)
IS  - 1520-037X (Linking)
VI  - 8
IP  - 2
DP  - 2005 Spring
TI  - Adverse events with concomitant amiodarone and statin therapy.
PG  - 95-7
AB  - The authors reviewed adverse events (AEs) reported to the United States Food and 
      Drug Administration to determine the percentage of statin-associated AE reports 
      with concurrent amiodarone use for simvastatin, atorvastatin, and pravastatin. 
      AEs affecting the following organ systems were analyzed: muscle, liver, pancreas, 
      and bone marrow. The percentage of simvastatin reports with concurrent amiodarone 
      use was 1.0%, compared with 0.7% of the atorvastatin-associated reports (p = not 
      significant). The percentage of pravastatin reports with concurrent amiodarone 
      use was 0.4% (p < 0.05 for pravastatin vs. simvastatin). Muscle toxicity was the 
      most commonly reported statin-amiodarone AE, accounting for 77% of the reports. 
      AEs tended to occur in older male patients (mean age, 76 years), who were on 
      multiple other medications (mean number of other medications, five). Clinicians 
      should be vigilant about muscle-related complaints in patients concomitantly 
      taking amiodarone, especially in elderly patients on multiple medications. Use of 
      a statin not metabolized through the cytochrome P450-3A4 system may be 
      appropriate in this setting.
FAU - Alsheikh-Ali, Alawi A
AU  - Alsheikh-Ali AA
AD  - Department of Medicine, Division of Cardiology, Preventive Cardiology Center, 
      Tufts-New England Medical Center, Boston, MA 02111, USA.
FAU - Karas, Richard H
AU  - Karas RH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prev Cardiol
JT  - Preventive cardiology
JID - 9813731
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Pyrroles)
RN  - A0JWA85V8F (Atorvastatin)
RN  - AGG2FN16EV (Simvastatin)
RN  - KXO2KT9N0G (Pravastatin)
RN  - N3RQ532IUT (Amiodarone)
SB  - IM
MH  - Adverse Drug Reaction Reporting Systems
MH  - Aged
MH  - Amiodarone/administration & dosage/*adverse effects
MH  - Atorvastatin
MH  - Drug Therapy, Combination
MH  - Female
MH  - Heptanoic Acids/administration & dosage/adverse effects
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/*adverse 
      effects
MH  - Male
MH  - Pravastatin/administration & dosage/adverse effects
MH  - Pyrroles/administration & dosage/adverse effects
MH  - Simvastatin/administration & dosage/adverse effects
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2005/04/30 09:00
MHDA- 2005/06/10 09:00
CRDT- 2005/04/30 09:00
PHST- 2005/04/30 09:00 [pubmed]
PHST- 2005/06/10 09:00 [medline]
PHST- 2005/04/30 09:00 [entrez]
AID - 10.1111/j.1520-037x.2005.4060.x [doi]
PST - ppublish
SO  - Prev Cardiol. 2005 Spring;8(2):95-7. doi: 10.1111/j.1520-037x.2005.4060.x.