PMID- 1586303
OWN - NLM
STAT- MEDLINE
DCOM- 19920618
LR  - 20190718
IS  - 0004-8682 (Print)
IS  - 0004-8682 (Linking)
VI  - 62
IP  - 2
DP  - 1992 Feb
TI  - Antibody responses following splenectomy: implications for the timing of 
      prophylactic vaccination.
PG  - 142-6
AB  - Antibody responses are reduced both in the short- and long-term after 
      splenectomy. It is not known if this reduction is more profound in the immediate 
      postoperative period compared to later, and consequently, whether there would be 
      an advantage in delaying prophylactic vaccination to ensure a greater antibody 
      response. To investigate this, the effect of splenectomy on the primary and 
      secondary antibody response to sheep red blood cells (SRBC) injected into the 
      peritoneum (IP) of adult male Porton rats was measured after either splenectomy 
      (Spx), sham splenectomy (Sham), anaesthesia only (Ans) or no procedure at all 
      (Con). There was no difference in the titres of antibody between the Con and the 
      Ans rats. There was no difference in the titres of antibody between the Sham and 
      Spx rats, but both had significantly lower titres than the Con rats. In a 
      separate experiment, rats were immunized 1 month or 1 year after splenectomy or 
      sham-splenectomy. One month after the operation the antibody response of the Sham 
      rats had increased and did not differ from that of Con rats, but in rats which 
      had been splenectomized there was a long-term suppression of the antibody 
      response, which did not improve for at least one year. The results suggest that, 
      in patients requiring splenectomy for trauma and not able to be vaccinated before 
      operation, there may be no advantage in delaying prophylactic vaccination 
      postoperatively.
FAU - Clayer, M T
AU  - Clayer MT
AD  - Department of Surgery, Royal Adelaide Hospital, South Australia.
FAU - Drew, P A
AU  - Drew PA
FAU - Jamieson, G G
AU  - Jamieson GG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Aust N Z J Surg
JT  - The Australian and New Zealand journal of surgery
JID - 0373115
SB  - IM
MH  - Animals
MH  - *Antibody Formation
MH  - Immunization Schedule
MH  - Male
MH  - Postoperative Period
MH  - Rats
MH  - *Splenectomy
MH  - Time Factors
MH  - *Vaccination
EDAT- 1992/02/01 00:00
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PHST- 1992/02/01 00:00 [pubmed]
PHST- 1992/02/01 00:01 [medline]
PHST- 1992/02/01 00:00 [entrez]
AID - 10.1111/j.1445-2197.1992.tb00013.x [doi]
PST - ppublish
SO  - Aust N Z J Surg. 1992 Feb;62(2):142-6. doi: 10.1111/j.1445-2197.1992.tb00013.x.