PMID- 15863226
OWN - NLM
STAT- MEDLINE
DCOM- 20050715
LR  - 20131121
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 160
IP  - 2
DP  - 2005 May 28
TI  - Ibotenic acid lesions of the medial prefrontal cortex block the development and 
      expression of 3,4-methylenedioxymethamphetamine-induced behavioral sensitization 
      in rats.
PG  - 304-11
AB  - There is ample evidence that plastic changes in the nervous system require the 
      excitatory amino acid transmission. This appears to be also the case for 
      psychostimulant-induced behavioral sensitization. More specifically the 
      glutamatergic input from the medial prefrontal cortex (mPFC) to the VTA and the 
      NAc appears to be involved in behavioral sensitization processes. However, 
      dissociations regarding the role of the mPFC with respect to the development and 
      expression of sensitization, as well as with respect to the psychostimulant being 
      studied (amphetamine versus cocaine) appear to exist. The present study examined 
      the role of the dorsal mPFC in the development and expression of 
      3,4-methylenedioxymethamphetamine (MDMA)-induced sensitization. Bilateral 
      ibotenic acid or sham lesions of the dorsal mPFC were performed 7 days prior to 
      or 4 days after a context-dependent sensitization-inducing regimen of MDMA (15 
      mg/kg i.p.) or saline. Rats were then challenged with MDMA (5 mg/kg i.p.) after 
      12 days of withdrawal. Ibotenic acid lesions did not affect the activating 
      effects of MDMA, but prevented the development and expression of MDMA 
      sensitization. Thus, the distance traveled during the development phase of 
      sensitization increased in sham-lesioned rats but not in ibotenic-lesioned 
      animals. Similarly, sham-lesioned rats showed a sensitized response when 
      challenged with MDMA after the withdrawal period, an effect not observed in 
      ibotenic-lesioned animals. These data reinforce the view that the dorsal mPFC is 
      involved in psychostimulant sensitization and more specifically they indicate 
      that the dorsal mPFC plays a key role in the development and expression of 
      MDMA-induced behavioral sensitization.
FAU - Ramos, Maria
AU  - Ramos M
AD  - Department of Pharmacology, School of Medicine, University of Navarra, Spain.
FAU - Goni-Allo, Beatriz
AU  - Goni-Allo B
FAU - Aguirre, Norberto
AU  - Aguirre N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain Diseases/physiopathology
MH  - Drug Interactions
MH  - Excitatory Amino Acid Agonists/*toxicity
MH  - Ibotenic Acid/*toxicity
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neural Inhibition/drug effects
MH  - Prefrontal Cortex/injuries/pathology/*physiology
MH  - Rats
MH  - Time Factors
EDAT- 2005/05/03 09:00
MHDA- 2005/07/16 09:00
CRDT- 2005/05/03 09:00
PHST- 2004/09/10 00:00 [received]
PHST- 2004/12/13 00:00 [revised]
PHST- 2004/12/16 00:00 [accepted]
PHST- 2005/05/03 09:00 [pubmed]
PHST- 2005/07/16 09:00 [medline]
PHST- 2005/05/03 09:00 [entrez]
AID - S0166-4328(04)00478-4 [pii]
AID - 10.1016/j.bbr.2004.12.010 [doi]
PST - ppublish
SO  - Behav Brain Res. 2005 May 28;160(2):304-11. doi: 10.1016/j.bbr.2004.12.010.