PMID- 15863896
OWN - NLM
STAT- MEDLINE
DCOM- 20051230
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 28
IP  - 5
DP  - 2005 May
TI  - Transdermal absorption of propofol in rats.
PG  - 870-5
AB  - Propofol (PF), a highly lipophilic anesthetic, has several desirable properties, 
      such as the rapid onset and cessation of its effects upon intravenous infusion. 
      In this study, the transdermal absorption of PF was investigated with the aim of 
      the development of an alternative route of administration. PF solutions 
      containing isopropyl myristate (IPM), ethanol or propylene glycol (PG) at various 
      concentrations were prepared and applied to the abdominal skin of rats. 
      Petrolatum and fatty alcohol propylene glycol (FAPG) ointments containing PF were 
      also prepared and applied to the dorsal skin. Eyelid opening was measured and the 
      ratio of the measured value to the initial value was calculated to evaluate the 
      level of the pharmacological effect of the preparation. The PG solution 
      containing 80% PF achieved higher plasma PF concentrations than the 100% PF 
      solution. The PF-FAPG ointment produced a higher plasma PF concentration than the 
      PF-petrolatum ointment. Furthermore, a drowsy state was confirmed after 
      transdermal administration of 42% PF-FAPG ointment. These results indicate that 
      the combination of PF and PG was appropriate for the transdermal absorption of 
      PF, and PF was absorbed through the rat skin to an extent sufficient to cause a 
      continuous sedative effect.
FAU - Takahashi, Yuri
AU  - Takahashi Y
AD  - Department of Drug Delivery Research, Hoshi University, Tokyo 142-8501, Japan. 
      taka-y@hoshi.ac.jp
FAU - Yamato, Keisuke
AU  - Yamato K
FAU - Akiyama, Hidero
AU  - Akiyama H
FAU - Tsuji, Kazuyuki
AU  - Tsuji K
FAU - Onishi, Hiraku
AU  - Onishi H
FAU - Machida, Yoshiharu
AU  - Machida Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Drug Carriers)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Chemistry, Pharmaceutical
MH  - Drug Carriers/administration & dosage/pharmacokinetics
MH  - Male
MH  - Propofol/*administration & dosage/blood/*pharmacokinetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin Absorption/*drug effects/physiology
EDAT- 2005/05/03 09:00
MHDA- 2005/12/31 09:00
CRDT- 2005/05/03 09:00
PHST- 2005/05/03 09:00 [pubmed]
PHST- 2005/12/31 09:00 [medline]
PHST- 2005/05/03 09:00 [entrez]
AID - JST.JSTAGE/bpb/28.870 [pii]
AID - 10.1248/bpb.28.870 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2005 May;28(5):870-5. doi: 10.1248/bpb.28.870.