PMID- 15866030
OWN - NLM
STAT- MEDLINE
DCOM- 20050822
LR  - 20101118
IS  - 0962-8924 (Print)
IS  - 0962-8924 (Linking)
VI  - 15
IP  - 5
DP  - 2005 May
TI  - Probing phosphoinositide functions in signaling and membrane trafficking.
PG  - 259-68
AB  - The inositol phospholipids (PIs) comprise a family of eight species with 
      different combinations of phosphate groups arranged around the inositol ring. PIs 
      are among the most versatile signaling molecules known, with key roles in 
      receptor-mediated signal transduction, actin remodeling and membrane trafficking. 
      Recent studies have identified effector proteins and specific lipid-binding 
      domains through which PIs signal. These lipid-binding domains can be used as 
      probes to further our understanding of the spatial and temporal control of 
      individual PI species. New layers of complexity revealed by the use of such 
      probes include the occurrence of PIs at intracellular locations, the 
      identification of phosphatidylinositol signaling hotspots and the presence of 
      non-membrane pools of PIs in cell nuclei.
FAU - Downes, C Peter
AU  - Downes CP
AD  - Division of Cell Signalling, School of Life Sciences, MSI/WTB Complex, University 
      of Dundee, Dundee DD1 5EH, Scotland, UK. c.p.downes@dundee.ac.uk
FAU - Gray, Alex
AU  - Gray A
FAU - Lucocq, John M
AU  - Lucocq JM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - 0 (Membrane Lipids)
RN  - 0 (Phosphatidylinositol 4,5-Diphosphate)
RN  - 0 (Phosphatidylinositols)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
MH  - Cell Membrane/metabolism
MH  - Intracellular Membranes/metabolism
MH  - Membrane Lipids/metabolism
MH  - Models, Biological
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphatidylinositol 4,5-Diphosphate/metabolism
MH  - Phosphatidylinositols/*metabolism
MH  - Protein Binding
MH  - Signal Transduction
RF  - 78
EDAT- 2005/05/04 09:00
MHDA- 2005/08/23 09:00
CRDT- 2005/05/04 09:00
PHST- 2005/05/04 09:00 [pubmed]
PHST- 2005/08/23 09:00 [medline]
PHST- 2005/05/04 09:00 [entrez]
AID - S0962-8924(05)00084-X [pii]
AID - 10.1016/j.tcb.2005.03.008 [doi]
PST - ppublish
SO  - Trends Cell Biol. 2005 May;15(5):259-68. doi: 10.1016/j.tcb.2005.03.008.