PMID- 15866653
OWN - NLM
STAT- MEDLINE
DCOM- 20050926
LR  - 20081121
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 37
IP  - 3
DP  - 2005 Apr
TI  - Lack of association of recipient MCP-1 gene promoter polymorphism with acute 
      graft rejection after orthotopic liver transplantation.
PG  - 1496-8
AB  - Acute graft rejection after orthotopic liver transplantation (OLT) is associated 
      with leukocyte infiltration of the graft. Monocyte chemoattractant protein-1 
      (MCP-1) is a beta-chemokine involved in the attraction and accumulation of 
      mononuclear granulocytes toward sites of inflammation. A biallelic polymorphism 
      (G/A) at position -2518 of the MCP-1 gene has been described. Cells obtained from 
      individuals with the GG or AG genotypes have been found to produce more MCP-1 
      than those obtained from individuals with the AA genotype. The goal of this study 
      was to assess the possible association between this polymorphism and 
      susceptibility to acute graft rejection after OLT. One hundred fifty Caucasian 
      liver transplant recipients from the South of Spain underwent genotyping using a 
      polymerase chain reaction (PCR) amplification followed by restriction fragment 
      length polymorphism (RFLP). No significant differences were observed when 
      patients with versus without acute rejection episodes were compared for the 
      distribution of -2518 MCP-1 genotypes. The present study supports the lack of 
      involvement of polymorphism at position -2518 (A/G) of the MCP-1 gene on the 
      susceptibility to acute allograft rejection among OLT recipients.
FAU - Franco-Lopez, E
AU  - Franco-Lopez E
AD  - Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
FAU - Gonzalez-Escribano, M F
AU  - Gonzalez-Escribano MF
FAU - Aguilera, I
AU  - Aguilera I
FAU - Pascasio, J M
AU  - Pascasio JM
FAU - Pareja, F
AU  - Pareja F
FAU - Bernardos, A
AU  - Bernardos A
FAU - Nunez-Roldan, A
AU  - Nunez-Roldan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Base Sequence
MH  - Chemokine CCL2/*genetics
MH  - DNA/blood/genetics/isolation & purification
MH  - DNA Primers
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Graft Rejection/epidemiology/*genetics
MH  - Humans
MH  - Liver Transplantation/*pathology
MH  - Male
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Retrospective Studies
EDAT- 2005/05/04 09:00
MHDA- 2005/09/27 09:00
CRDT- 2005/05/04 09:00
PHST- 2005/05/04 09:00 [pubmed]
PHST- 2005/09/27 09:00 [medline]
PHST- 2005/05/04 09:00 [entrez]
AID - S0041-1345(05)00163-6 [pii]
AID - 10.1016/j.transproceed.2005.02.047 [doi]
PST - ppublish
SO  - Transplant Proc. 2005 Apr;37(3):1496-8. doi: 10.1016/j.transproceed.2005.02.047.