PMID- 15867334
OWN - NLM
STAT- MEDLINE
DCOM- 20050706
LR  - 20181201
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 135
IP  - 5
DP  - 2005 May
TI  - Plasma ghrelin concentrations are lower in binge-eating disorder.
PG  - 1326-30
AB  - Binge-eating disorder (BED), characterized by binge meals without purging 
      afterward, is found in about 30% of obese individuals seeking treatment. The 
      study objective was to ascertain abnormalities in hormones influencing appetite 
      in BED, especially ghrelin, an appetite-stimulating peptide, which was expected 
      to be elevated. Measurements were made of plasma insulin, leptin, glucagon, 
      cholecystokinin, and ghrelin, as well as glucose following an overnight 12-h 
      fast, prior to and after ingestion (from 0 to 5 min) of a nutritionally complete 
      liquid meal (1254 kJ) at 0830 h, at -15, 0, 5, 15, 30, 60, 90, and 120 min. 
      Appetite ratings including hunger and fullness were also obtained. An 
      acetaminophen tracer was used to assess gastric emptying rate. Three groups of 
      comparably obese women (BMI = 35.9 +/- 5.5; % body fat = 44.9 +/- 4.7) 
      participated: 12 nonbinge eating normals (NB), 14 subthreshold BED, and 11 BED. 
      The BED subjects, compared to NB subjects, had lower baseline ghrelin 
      concentrations prior to the meal, a lower area under the curve (AUC), with lower 
      levels at 5, 15, 30, 90, and 120 min, and a smaller decline in ghrelin postmeal 
      (all P < 0.03). The other blood values did not differ among groups, and neither 
      did gastric emptying rate nor ratings of fullness. The BED subjects were then 
      randomly assigned to treatment with cognitive-behavior therapy and diet (n = 5) 
      or to a wait-list control (n = 4). Baseline ghrelin (P = 0.01) and AUC increased 
      (P = 0.02), across both conditions, in which most subjects (7 of 9) stopped binge 
      eating. The lower fasting and postmeal plasma ghrelin levels in BED are 
      consistent with lower ghrelin levels in obese compared to lean individuals and 
      suggests downregulation by binge eating.
FAU - Geliebter, Allan
AU  - Geliebter A
AD  - Department of Medicine, New York Obesity Research Center, St. Luke's Roosevelt 
      Hospital Center, Columbia University College of Physicians and Surgeons, New 
      York, NY, USA. ag58@columbia.edu
FAU - Gluck, Marci E
AU  - Gluck ME
FAU - Hashim, Sami A
AU  - Hashim SA
LA  - eng
GR  - DK54318/DK/NIDDK NIH HHS/United States
GR  - R03 DK068603-02/DK/NIDDK NIH HHS/United States
GR  - DK 26687/DK/NIDDK NIH HHS/United States
GR  - M01 RR0064529/RR/NCRR NIH HHS/United States
GR  - R03 DK068603/DK/NIDDK NIH HHS/United States
GR  - R03 DK068603-01A2/DK/NIDDK NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Blood Glucose)
RN  - 0 (Ghrelin)
RN  - 0 (Leptin)
RN  - 0 (Peptide Hormones)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Adult
MH  - Appetite/physiology
MH  - Area Under Curve
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Bulimia/*blood/therapy
MH  - Cholecystokinin/blood
MH  - Cognitive Behavioral Therapy
MH  - Diet
MH  - Female
MH  - Ghrelin
MH  - Humans
MH  - Leptin/blood
MH  - Obesity/blood
MH  - Peptide Hormones/*blood
MH  - Postprandial Period
MH  - Premenopause
MH  - Reference Values
EDAT- 2005/05/04 09:00
MHDA- 2005/07/07 09:00
CRDT- 2005/05/04 09:00
PHST- 2005/05/04 09:00 [pubmed]
PHST- 2005/07/07 09:00 [medline]
PHST- 2005/05/04 09:00 [entrez]
AID - 135/5/1326 [pii]
AID - 10.1093/jn/135.5.1326 [doi]
PST - ppublish
SO  - J Nutr. 2005 May;135(5):1326-30. doi: 10.1093/jn/135.5.1326.