PMID- 15870178
OWN - NLM
STAT- MEDLINE
DCOM- 20050919
LR  - 20240316
IS  - 0006-4971 (Print)
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 106
IP  - 4
DP  - 2005 Aug 15
TI  - Genetic influences on peripheral blood cell counts: a study in baboons.
PG  - 1210-4
AB  - Interperson differences in peripheral blood cell counts in healthy individuals 
      result from genetic and environmental influences. We used multivariate genetic 
      analyses to assess the relative impact of genes and environment on baseline blood 
      cell counts and indices using a pedigreed colony of baboons, an animal with 
      well-documented analogies to human blood physiology. After accounting for age, 
      sex, and weight, we found that genetic influences explain a significant 
      proportion of the remaining variability, ranging from a low of 13.7% for mean 
      corpuscular hemoglobin concentration (MCHC) to a high of 72.4% for red blood cell 
      (RBC) number. Genes influence 38.5% of the variation in baseline white blood cell 
      (WBC) count, a characteristic that correlates with mortality in both the general 
      human population and clinically defined subgroups such as individuals with 
      sickle-cell disease. We examined the interaction between pairs of traits and 
      identified those that share common genetic influences (pleiotropy). We 
      unexpectedly observed that the same gene or group of genes influences both WBC 
      count and mean platelet volume (MPV). We anticipate that this approach will 
      ultimately lead to discovery of novel insights into the biology of related 
      traits, and ultimately identify important genes that affect hematopoiesis.
FAU - Mahaney, Michael C
AU  - Mahaney MC
AD  - Department of Genetics, Southwest Foundation for Biomedical Research, San 
      Antonio, TX, USA.
FAU - Brugnara, Carlo
AU  - Brugnara C
FAU - Lease, Loren R
AU  - Lease LR
FAU - Platt, Orah S
AU  - Platt OS
LA  - eng
GR  - P01 HL028972/HL/NHLBI NIH HHS/United States
GR  - P51 RR013086/RR/NCRR NIH HHS/United States
GR  - R01 HL054141/HL/NHLBI NIH HHS/United States
GR  - R01 HL068922/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050503
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Animals
MH  - Blood Cell Count
MH  - Blood Cells/*cytology
MH  - Erythrocyte Indices
MH  - *Genetic Variation
MH  - Hematologic Tests
MH  - Inheritance Patterns
MH  - Multivariate Analysis
MH  - Papio
PMC - PMC1895191
EDAT- 2005/05/05 09:00
MHDA- 2005/09/20 09:00
PMCR- 2006/08/15
CRDT- 2005/05/05 09:00
PHST- 2005/05/05 09:00 [pubmed]
PHST- 2005/09/20 09:00 [medline]
PHST- 2005/05/05 09:00 [entrez]
PHST- 2006/08/15 00:00 [pmc-release]
AID - S0006-4971(20)53126-1 [pii]
AID - 01061210 [pii]
AID - 10.1182/blood-2004-12-4863 [doi]
PST - ppublish
SO  - Blood. 2005 Aug 15;106(4):1210-4. doi: 10.1182/blood-2004-12-4863. Epub 2005 May 
      3.