PMID- 15870510
OWN - NLM
STAT- MEDLINE
DCOM- 20050729
LR  - 20061115
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 51
IP  - 4
DP  - 2005
TI  - Relationship between class I and II HLA antigens in schizophrenia and eye 
      movement disturbances: a preliminary study.
PG  - 204-10
AB  - The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to 
      be associated with both the vulnerability to schizophrenia and presence of eye 
      movement disturbances (EMD). The aim of this preliminary study was to investigate 
      how individual class I and II HLA antigens in schizophrenic patients may be 
      related to schizophrenia and to the intensity of two kinds of EMD: fixation and 
      smooth pursuit. The incidence of HLA antigens was compared between 40 
      schizophrenic patients (17 male, 23 female) and 198 healthy control subjects (112 
      male, 86 female). In schizophrenic patients, the intensity of EMD assessed by 
      infrared reflectometry and quantified on a scale from 0 to 3 was correlated with 
      the incidence of HLA antigens. A number of differences regarding HLA antigens 
      were found between schizophrenic patients and healthy subjects. Significant 
      correlation was also obtained between some EMD and a number of HLA antigens. 
      Antigens A24 and A28 were found to occur in different frequencies in 
      schizophrenic patients and healthy control subjects. They also correlated with 
      EMD on the fixation and smooth pursuit tests. The results obtained show an 
      association between HLA antigens and EMD as an endophenotypic marker of 
      schizophrenia, and may add to other findings on susceptibility loci for 
      schizophrenia on chromosome 6p21. A limitation of this study is a small number of 
      investigated patients with schizophrenia.
CI  - Copyright (c) 2005 S. Karger AG, Basel.
FAU - Bogacki, Przemyslaw A
AU  - Bogacki PA
AD  - Department of Adult Psychiatry, University of Medical Sciences, ul. Szpitalna 
      27/33, 60-572 Poznan, Poland.
FAU - Borkowska, Alina
AU  - Borkowska A
FAU - Wojtanowska-Bogacka, Malgorzata
AU  - Wojtanowska-Bogacka M
FAU - Rybakowski, Janusz K
AU  - Rybakowski JK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20050504
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - HLA Antigens/*classification/genetics/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ocular Motility Disorders/etiology/*metabolism
MH  - Schizophrenia/complications/genetics/*metabolism
MH  - Sex Factors
MH  - Statistics, Nonparametric
EDAT- 2005/05/05 09:00
MHDA- 2005/07/30 09:00
CRDT- 2005/05/05 09:00
PHST- 2005/05/05 09:00 [pubmed]
PHST- 2005/07/30 09:00 [medline]
PHST- 2005/05/05 09:00 [entrez]
AID - 85595 [pii]
AID - 10.1159/000085595 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2005;51(4):204-10. doi: 10.1159/000085595. Epub 2005 May 4.