PMID- 15870857
OWN - NLM
STAT- MEDLINE
DCOM- 20050726
LR  - 20091119
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 26
IP  - 6
DP  - 2005 Jun
TI  - Expression of bone morphogenetic protein 2 in breast cancer cells inhibits 
      hypoxic cell death.
PG  - 1465-70
AB  - BMP-2 is involved in the fetal and postnatal development of the mammary gland but 
      has also been detected in breast cancer cells. To clarify the biological role of 
      BMP-2 in breast cancer, we used the human breast cancer cell line MCF-7. 
      Incubation with BMP-2 under serum-free conditions induced activation of the 
      mitogen activated protein kinases (MAPKs) ERK1/2 and the basic helix-loop-helix 
      transcription factors Id-1, proteins that can protect from apoptosis. Stably 
      transfected MCF-7 cells overexpressing BMP-2 revealed significantly increased 
      resistance to hypoxia-induced apoptosis compared to empty vector controls. 
      Cytoplasmic BMP-2/4 protein expression was detected in carcinoma cells of 81 
      samples of invasive breast cancer in contrast to adjacent normal mammary 
      epithelial cells. BMP-2/4 expression did not correlate with common prognostic 
      parameters and was not associated with relapse-free or overall survival. We 
      conclude that BMP-2/4 expression is reactivated in invasive breast cancer and 
      part of an autocrine/paracrine mechanism rescuing malignant cells from hypoxic 
      cell death via activation of the MAPK and Id-1 pathway.
FAU - Raida, Martin
AU  - Raida M
AD  - University Hospital of Leipzig, Department of Hematology and Oncology, D-04103 
      Leipzig, Germany. martin.raida@medizin.uni-leipzig.de
FAU - Clement, Joachim H
AU  - Clement JH
FAU - Ameri, Kurosh
AU  - Ameri K
FAU - Han, Cheng
AU  - Han C
FAU - Leek, Russell D
AU  - Leek RD
FAU - Harris, Adrian L
AU  - Harris AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (BMP2 protein, human)
RN  - 0 (BMP4 protein, human)
RN  - 0 (Bone Morphogenetic Protein 2)
RN  - 0 (Bone Morphogenetic Protein 4)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Bone Morphogenetic Protein 2
MH  - Bone Morphogenetic Protein 4
MH  - Bone Morphogenetic Proteins/analysis/*physiology
MH  - Breast Neoplasms/metabolism/mortality/*pathology
MH  - Cell Death
MH  - Cell Hypoxia
MH  - Cell Line, Tumor
MH  - Female
MH  - Humans
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Prognosis
MH  - Transforming Growth Factor beta/analysis/*physiology
EDAT- 2005/05/05 09:00
MHDA- 2005/07/27 09:00
CRDT- 2005/05/05 09:00
PHST- 2005/05/05 09:00 [pubmed]
PHST- 2005/07/27 09:00 [medline]
PHST- 2005/05/05 09:00 [entrez]
PST - ppublish
SO  - Int J Oncol. 2005 Jun;26(6):1465-70.