PMID- 15875085
OWN - NLM
STAT- MEDLINE
DCOM- 20050721
LR  - 20211130
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 52
IP  - 3
DP  - 2005
TI  - EGFR LI and Ki-67 LI are independent prognostic parameters influencing survivals 
      of surgically treated squamous cell lung cancer patients.
PG  - 231-7
AB  - In literature there are still opinion differences concerning the prognostic 
      significance of epidermal growth factor receptor (EGFR) expression and 
      proliferative potential in patients with non small cell lung cancer (NSCLC). This 
      prompted us to study those parameters. The Ki-67 labeling index (Ki-67 LI), EGFR 
      labeling index (EGFR LI), and mitotic index (MI) were analyzed in the group of 78 
      consecutive, surgically treated squamous cell lung cancer (SqCLC) patients. The 
      expression of Ki-67 and EGFR protein was visualized on formalin fixed, paraffin 
      embedded sections using immunohistochemistry (IHC). Mitotic index was assessed on 
      formalin fixed, paraffin embedded sections, stained with hematoxylin and eosin 
      using morphological criteria. Mean values of Ki-67 LI and MI were higher for 
      G2+G3 tumors than for G1 tumors. EGFR LI was higher for G1+G2 than for G3 tumors, 
      and for pT3 than for pT1+pT2 tumors. Patients having tumors with Ki-67 < or =28% 
      or (EGFR LI < or =13% or EGFR LI >80%) survived significantly shorter than those 
      having tumors with Ki-67 LI >28% or 13%< EGFR LI < or =80%. In multivariate 
      analysis, 13%> or = EGFR LI <80% and Ki-67 LI < or =28% were independent negative 
      prognostic parameters influencing survivals of SqCLC patients.
FAU - Niemiec, J
AU  - Niemiec J
AD  - Laboratory of Radiation Biology, Centre of Oncology, Krakow, Poland. 
      joannna@eikon.pl
FAU - Kolodziejski, L
AU  - Kolodziejski L
FAU - Dyczek, S
AU  - Dyczek S
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 0 (Ki-67 Antigen)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/pathology
MH  - Carcinoma, Squamous Cell/metabolism/*pathology/surgery
MH  - ErbB Receptors/analysis/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/analysis/*metabolism
MH  - Lung Neoplasms/metabolism/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Mitotic Index
MH  - Prognosis
MH  - Survival Analysis
EDAT- 2005/05/06 09:00
MHDA- 2005/07/22 09:00
CRDT- 2005/05/06 09:00
PHST- 2005/05/06 09:00 [pubmed]
PHST- 2005/07/22 09:00 [medline]
PHST- 2005/05/06 09:00 [entrez]
PST - ppublish
SO  - Neoplasma. 2005;52(3):231-7.