PMID- 15876152
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20091119
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 15
IP  - 4
DP  - 2005 Apr
TI  - Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat 
      cerebellar cortex.
PG  - 314-9
AB  - Steroid receptor coactivator-1 (SRC-1) interacts with nuclear hormone receptors 
      (NRs) to mediate their action in a ligand-dependent manner. Among such ligands, 
      thyroid hormone (TH) is particularly crucial for brain development. The 
      expression of many TH target genes is regulated by TH only for a limited critical 
      period, although TH receptor (TR) expression is not greatly altered after such 
      period. To alter TH sensitivity, other factors may be involved. We thus examined 
      the changes in SRC-1 expression during postnatal development in the rat 
      cerebellum by immunohistochemistry and Western blotting. Strong SRC-1 
      immunoreactivity (IR) was constantly seen in Purkinje cell from postnatal days 
      (P) 2 to P30. SRC-1 IR was also constantly observed in the internal granule cell 
      layer. However, it was negative in the external granule cell layer at P2 and P7, 
      whereas a weak IR was detected in the premigratory zone at P15. SRC-1 IR was 
      detected in the molecular layer after P15. These results indicate that although 
      TR is almost ubiquitously expressed in the developing cerebellum, the TH 
      sensitivity could vary in each subset of cells. By Western blotting, SRC-1 
      protein level was greatest at P15, at which time TH action may be obvious. Taken 
      together, the differential expression of SRC-1 may be crucial in mediating TH 
      action during cerebellar development.
FAU - Yousefi, Behnaz
AU  - Yousefi B
AD  - United Graduate School of Agricultural Science, Tokyo University of Agriculture 
      and Technology, Fuchu, Tokyo, Japan.
FAU - Jingu, Hisaka
AU  - Jingu H
FAU - Ohta, Misae
AU  - Ohta M
FAU - Umezu, Motoaki
AU  - Umezu M
FAU - Koibuchi, Noriyuki
AU  - Koibuchi N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Thyroid Hormones)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Cerebellar Cortex/*chemistry
MH  - Female
MH  - Histone Acetyltransferases
MH  - Immunohistochemistry
MH  - Nuclear Receptor Coactivator 1
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thyroid Hormones/pharmacology
MH  - Transcription Factors/*analysis
EDAT- 2005/05/07 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/05/07 09:00
PHST- 2005/05/07 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/05/07 09:00 [entrez]
AID - 10.1089/thy.2005.15.314 [doi]
PST - ppublish
SO  - Thyroid. 2005 Apr;15(4):314-9. doi: 10.1089/thy.2005.15.314.