PMID- 15876794
OWN - NLM
STAT- MEDLINE
DCOM- 20050617
LR  - 20220409
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 67
IP  - 4
DP  - 2005 Apr
TI  - Immunohistochemical analysis of expression patterns of tumor necrosis factor 
      receptors on lymphoma cells in enzootic bovine leukosis.
PG  - 425-32
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been reported to be associated with 
      the progression of lymphoproliferative neoplastic diseases and retroviral 
      infections. Hence we examined immunohistochemically the expression patterns of 
      TNF-receptors (TNF-RI and RII) on lymphoma cells derived from the 29 cases of 
      enzootic bovine leukosis (EBL). Lymphomas obtained in 29 animals with EBL were 
      histopathologically classified into three types: diffuse mixed type (10 cases), 
      diffuse large type (9 cases), and diffuse large cleaved type (10 cases). 
      Immunohistochemically using a monoclonal antibody to a bovine lymphocyte surface 
      antigen, the lymphomas were classified into three phenotypes: B-1a (CD5+/CD11b+), 
      B-1b (CD5-/CD11b+) and B-2 (conventional B) (CD5-/CD11b-). Interestingly, the 
      lymphoma cells in all animals expressed TNF-RII, but not TNF-RI. Although, in 
      EBL, lymphoma cells of which the histopathological and immunological property 
      differs has been formed, the expression patterns of TNF-Rs had the universality 
      in all lymphoma cells. TNF-RII, which induces cell proliferation, was expressed 
      but TNF-RI, which induces cell apoptosis was not expressed on all lymphoma cells, 
      suggesting that TNF-Rs play an important role in the malignant proliferation of B 
      cells and formation of lymphomas in EBL.
FAU - Ikeda, Manabu
AU  - Ikeda M
AD  - Department of Pathogenic Veterinary Science, The United Graduate School of 
      Veterinary Sciences, Gifu University, Japan.
FAU - Konnai, Satoru
AU  - Konnai S
FAU - Onuma, Misao
AU  - Onuma M
FAU - Ishiguro, Naotaka
AU  - Ishiguro N
FAU - Goryo, Masanobu
AU  - Goryo M
FAU - Okada, Kosuke
AU  - Okada K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - I223NX31W9 (Fluorescein-5-isothiocyanate)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/metabolism
MH  - B-Lymphocytes/*metabolism
MH  - Cattle
MH  - Cattle Diseases/*metabolism
MH  - Enzootic Bovine Leukosis/*metabolism
MH  - Flow Cytometry
MH  - Fluorescein-5-isothiocyanate
MH  - Fluorescent Antibody Technique, Indirect
MH  - *Gene Expression Regulation, Neoplastic
MH  - Immunohistochemistry
MH  - Receptors, Tumor Necrosis Factor/*metabolism
EDAT- 2005/05/07 09:00
MHDA- 2005/06/18 09:00
CRDT- 2005/05/07 09:00
PHST- 2005/05/07 09:00 [pubmed]
PHST- 2005/06/18 09:00 [medline]
PHST- 2005/05/07 09:00 [entrez]
AID - JST.JSTAGE/jvms/67.425 [pii]
AID - 10.1292/jvms.67.425 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2005 Apr;67(4):425-32. doi: 10.1292/jvms.67.425.