PMID- 15877740
OWN - NLM
STAT- MEDLINE
DCOM- 20050614
LR  - 20081121
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 129
IP  - 4
DP  - 2005 May
TI  - Relevance of the criteria commonly used to diagnose myeloproliferative disorder 
      in patients with splanchnic vein thrombosis.
PG  - 553-60
AB  - Myeloproliferative disorders (MPD) are reported in 25-65% of patients with 
      splanchnic vein thrombosis (SVT). Diagnostic criteria for MPD have not been fully 
      established in this context. Using clusters of abnormal megakaryocytes in bone 
      marrow (BM) biopsy as a reference standard for Philadelphia negative MPD, we 
      assessed the relevance of other criteria currently recommended for the diagnosis 
      of MPD in SVT (128 consecutive SVT patients). First, usual criteria were compared 
      with BM results: endogenous erythroid colony formation (EEC) was strongly 
      correlated with BM results; splenomegaly, blood cell count, total red cell 
      volume, erythropoietin level and cytogenetic were much less accurate. Then, 
      patients were assigned to three groups according to the combination of BM and EEC 
      findings (group I: both present; group II: both absent; group III: other 
      patients); clinical presentation and outcome were compared in each group. At a 
      mean follow-up of 6.09 +/- 6.6 years, progression to a severe form of MPD 
      occurred in 7 of 31 group I patients (23%), in 1 of 34 group III patients (3%) 
      and 0 of 63 group II patients. The combination of marked splenomegaly and 
      platelet count >200 x 10(9)/l was restricted to groups I and III. In conclusion, 
      in patients with SVT, BM findings and EEC allowed the diagnosis of MPD at risk of 
      aggravation. Marked splenomegaly in association with platelet counts >200 x 
      10(9)/l constitute a simple index with high specificity but low sensitivity.
FAU - Chait, Yasmine
AU  - Chait Y
AD  - Service d'Hematologie Clinique, Service d'Anatomie et de Cytologie Pathologiques, 
      Service d'Immunohematologie, Service d'Hepatologie, Hopital Beaujon (Clichy), 100 
      Boulevard General Leclerc, 92218 Clichy, France.
FAU - Condat, Bertrand
AU  - Condat B
FAU - Cazals-Hatem, Dominique
AU  - Cazals-Hatem D
FAU - Rufat, Pierre
AU  - Rufat P
FAU - Atmani, Sai
AU  - Atmani S
FAU - Chaoui, Driss
AU  - Chaoui D
FAU - Guilmin, Francoise
AU  - Guilmin F
FAU - Kiladjian, Jean Jacques
AU  - Kiladjian JJ
FAU - Plessier, Aurelie
AU  - Plessier A
FAU - Denninger, Marie Helene
AU  - Denninger MH
FAU - Casadevall, Nicole
AU  - Casadevall N
FAU - Valla, Dominique
AU  - Valla D
FAU - Briere, Jean B
AU  - Briere JB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Bone Marrow Cells/pathology
MH  - Cytogenetic Analysis
MH  - Erythrocyte Volume
MH  - Erythroid Precursor Cells/pathology
MH  - Erythropoietin/analysis
MH  - Follow-Up Studies
MH  - Humans
MH  - Megakaryocytes/pathology
MH  - Myeloproliferative Disorders/complications/*diagnosis/pathology
MH  - Phenotype
MH  - Platelet Count
MH  - Sensitivity and Specificity
MH  - *Splanchnic Circulation
MH  - Splenomegaly/etiology
MH  - Statistics, Nonparametric
MH  - Venous Thrombosis/*complications/pathology
EDAT- 2005/05/10 09:00
MHDA- 2005/06/15 09:00
CRDT- 2005/05/10 09:00
PHST- 2005/05/10 09:00 [pubmed]
PHST- 2005/06/15 09:00 [medline]
PHST- 2005/05/10 09:00 [entrez]
AID - BJH5490 [pii]
AID - 10.1111/j.1365-2141.2005.05490.x [doi]
PST - ppublish
SO  - Br J Haematol. 2005 May;129(4):553-60. doi: 10.1111/j.1365-2141.2005.05490.x.