PMID- 15877919
OWN - NLM
STAT- MEDLINE
DCOM- 20050825
LR  - 20190906
IS  - 0029-6651 (Print)
IS  - 0029-6651 (Linking)
VI  - 64
IP  - 1
DP  - 2005 Feb
TI  - Fatty acids and the metabolic syndrome.
PG  - 23-9
AB  - The metabolic syndrome is a very common condition, characterised by insulin 
      resistance, dyslipidaemia, abdominal obesity and hypertension, that is associated 
      with a high risk of type 2 diabetes mellitus (T2DM) and CVD. Obesity is a key 
      aetiological factor in the development of the metabolic syndrome. In light of the 
      increasing prevalence of obesity, there is a high requirement to reduce the 
      impact of the adverse health effects associated with the metabolic syndrome. The 
      aetiological role of nutrient-derived metabolic stressors, in particular fatty 
      acids, in the development of obesity and the metabolic syndrome is explored. 
      Also, the evidence that pro-inflammatory stressors may predispose to 
      obesity-induced insulin resistance is reviewed. The present paper explores the 
      concept that reducing the impact of metabolic and inflammatory stressors may 
      reduce the adverse health effects of obesity and slow the progression towards the 
      metabolic syndrome and T2DM. Evidence from human dietary intervention studies 
      that have investigated the potential therapeutic effects of dietary fatty acid 
      modification is explored. The present review highlights the requirement to take 
      account of genetic background, within the context of nutrient regulation of gene 
      expression and individual responsiveness to dietary therapy. This approach will 
      further the understanding of the interaction between fatty acids in the 
      pathogenesis and progression of the metabolic syndrome.
FAU - Roche, Helen M
AU  - Roche HM
AD  - Nutrigenomics Research Group, Department of Clinical Medicine, Institute of 
      Molecular Medicine, Trinity College, Dublin, Republic of Ireland. hmroche@tcd.ie
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Proc Nutr Soc
JT  - The Proceedings of the Nutrition Society
JID - 7505881
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Animals
MH  - Dietary Fats/*administration & dosage
MH  - Fatty Acids/administration & dosage/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Insulin Resistance
MH  - Metabolic Syndrome/diet therapy/*etiology/prevention & control
MH  - Obesity/*complications/diet therapy/epidemiology
RF  - 52
EDAT- 2005/05/10 09:00
MHDA- 2005/08/27 09:00
CRDT- 2005/05/10 09:00
PHST- 2005/05/10 09:00 [pubmed]
PHST- 2005/08/27 09:00 [medline]
PHST- 2005/05/10 09:00 [entrez]
AID - S0029665105000042 [pii]
AID - 10.1079/pns2004405 [doi]
PST - ppublish
SO  - Proc Nutr Soc. 2005 Feb;64(1):23-9. doi: 10.1079/pns2004405.