PMID- 15878731
OWN - NLM
STAT- MEDLINE
DCOM- 20050721
LR  - 20161019
IS  - 0278-2626 (Print)
IS  - 0278-2626 (Linking)
VI  - 58
IP  - 1
DP  - 2005 Jun
TI  - Interval-timing deficits in individuals at high risk for schizophrenia.
PG  - 109-18
AB  - A duration-bisection procedure was used to study the effects of signal modality 
      and divided attention on duration classification in participants at high genetic 
      risk for schizophrenia (HrSz), major affective disorder (HrAff), and normal 
      controls (NC). Participants learned short and long target durations during 
      training and classified probe durations during test. All groups classified visual 
      signals as shorter than equivalent duration auditory signals. However, the 
      difference between auditory and visual signal classification was significantly 
      larger for the HrSz group than for the NC group. We posit a model in which there 
      is a clock rate difference between auditory and visual signals due to an 
      attentional effect at the level of a mode switch that gates pulses into an 
      accumulator. This attentionally mediated clock rate difference was larger for the 
      HrSz participants than for the NC participants, resulting in a larger 
      auditory/visual difference for the HrSz group.
FAU - Penney, Trevor B
AU  - Penney TB
AD  - Department of Psychology, Chinese University of Hong Kong, Shatin, N.T., Hong 
      Kong, Hong Kong. tpenney@psy.cuhk.edu.hk
FAU - Meck, Warren H
AU  - Meck WH
FAU - Roberts, Simone A
AU  - Roberts SA
FAU - Gibbon, John
AU  - Gibbon J
FAU - Erlenmeyer-Kimling, L
AU  - Erlenmeyer-Kimling L
LA  - eng
GR  - R01 MH019560/MH/NIMH NIH HHS/United States
GR  - R37 MH019560/MH/NIMH NIH HHS/United States
GR  - MH19560/MH/NIMH NIH HHS/United States
GR  - MH20906/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20041202
PL  - United States
TA  - Brain Cogn
JT  - Brain and cognition
JID - 8218014
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Attention/*physiology
MH  - Child
MH  - Family Health
MH  - Female
MH  - *Field Dependence-Independence
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Mood Disorders/diagnosis/genetics/*physiopathology
MH  - Photic Stimulation
MH  - Reference Values
MH  - Risk Factors
MH  - Schizophrenia/diagnosis/genetics/*physiopathology
MH  - Time Perception/*physiology
EDAT- 2005/05/10 09:00
MHDA- 2005/07/22 09:00
CRDT- 2005/05/10 09:00
PHST- 2004/09/16 00:00 [received]
PHST- 2004/09/16 00:00 [accepted]
PHST- 2005/05/10 09:00 [pubmed]
PHST- 2005/07/22 09:00 [medline]
PHST- 2005/05/10 09:00 [entrez]
AID - S0278-2626(04)00283-0 [pii]
AID - 10.1016/j.bandc.2004.09.012 [doi]
PST - ppublish
SO  - Brain Cogn. 2005 Jun;58(1):109-18. doi: 10.1016/j.bandc.2004.09.012. Epub 2004 
      Dec 2.