PMID- 15878889
OWN - NLM
STAT- MEDLINE
DCOM- 20051028
LR  - 20140217
IS  - 0006-3363 (Print)
IS  - 0006-3363 (Linking)
VI  - 73
IP  - 3
DP  - 2005 Sep
TI  - Linking two immuno-suppressive molecules: indoleamine 2,3 dioxygenase can modify 
      HLA-G cell-surface expression.
PG  - 571-8
AB  - Nonclassical human leukocyte antigen (HLA) class I molecule HLA-G and indoleamine 
      2,3 dioxygenase (INDO) in humans and mice, respectively, have been shown to play 
      crucial immunosuppressive roles in fetal-maternal tolerance. HLA-G inhibits 
      natural killer and T cell function by high-affinity interaction with inhibitory 
      receptors, and INDO acts by depleting the surrounding microenvironment of the 
      essential amino acid tryptophan, thus inhibiting T cell proliferation. We 
      investigated whether HLA-G expression and INDO function were linked. Working with 
      antigen-presenting cell (APC) lines and monocytes, we found that functional 
      inhibition of INDO by 1-methyl-tryptophan induced cell surface expression of 
      HLA-G1 by HLA-G1-negative APCs that were originally cell-surface negative, and 
      that in reverse, the functional boost of INDO by high concentrations of 
      tryptophan induced a complete loss of HLA-G1 cell surface expression by APCs that 
      were originally cell-surface HLA-G1-positive. This mechanism was shown to be 
      posttranslational because HLA-G protein cell contents remained unaffected by the 
      treatments used. Furthermore, HLA-G cell surface expression regulation by INDO 
      seems to relate to INDO function, but not to tryptophan catabolism itself. 
      Potential implications in fetal-maternal tolerance are discussed.
FAU - Gonzalez-Hernandez, Alvaro
AU  - Gonzalez-Hernandez A
AD  - Clinica Universitaria de Navarra, 31080 Pamplona, Navarra, Spain.
FAU - LeMaoult, Joel
AU  - LeMaoult J
FAU - Lopez, Ana
AU  - Lopez A
FAU - Alegre, Estibaliz
AU  - Alegre E
FAU - Caumartin, Julien
AU  - Caumartin J
FAU - Le Rond, Solene
AU  - Le Rond S
FAU - Daouya, Marina
AU  - Daouya M
FAU - Moreau, Philippe
AU  - Moreau P
FAU - Carosella, Edgardo D
AU  - Carosella ED
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050504
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 8DUH1N11BX (Tryptophan)
RN  - EC 1.13.11.11 (Tryptophan Oxygenase)
SB  - IM
MH  - Cell Line
MH  - HLA Antigens/*biosynthesis
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*biosynthesis
MH  - Humans
MH  - Monocytes/immunology
MH  - Protein Processing, Post-Translational/drug effects/*physiology
MH  - Tryptophan/analogs & derivatives/pharmacology/physiology
MH  - Tryptophan Oxygenase/*metabolism
MH  - Up-Regulation
EDAT- 2005/05/10 09:00
MHDA- 2005/10/29 09:00
CRDT- 2005/05/10 09:00
PHST- 2005/05/10 09:00 [pubmed]
PHST- 2005/10/29 09:00 [medline]
PHST- 2005/05/10 09:00 [entrez]
AID - biolreprod.105.040089 [pii]
AID - 10.1095/biolreprod.105.040089 [doi]
PST - ppublish
SO  - Biol Reprod. 2005 Sep;73(3):571-8. doi: 10.1095/biolreprod.105.040089. Epub 2005 
      May 4.