PMID- 15879415
OWN - NLM
STAT- MEDLINE
DCOM- 20051110
LR  - 20061115
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 172
IP  - 5
DP  - 2005 Sep 1
TI  - Pulmonary dendritic cells.
PG  - 530-51
AB  - Dendritic cells (DCs) are leukocytes that are emerging as chief orchestrators of 
      immune responses. The crucial task of DCs is the continuous surveillance of 
      antigen-exposed sites throughout the body, and their unique responsibility is to 
      decide whether to present sampled antigen in an immunogenic or tolerogenic way. 
      Any misstep can either lead to a flawed immune defense or to allergy, even 
      autoimmunity. It comes as no surprise that the lungs become increasingly the 
      subject of DC-related investigations, as they represent a vast interface between 
      the body and the outer world. This constitutes an enormous challenge for the 
      immune system: "firing up" immune responses inappropriately could have 
      devastating results for the fragile gas exchange structures. Evidence accumulates 
      that DCs play a pivotal role in maintaining the delicate balance between 
      tolerance and active immune response in our respiratory system. The exponentially 
      growing body of DC-related publications is a big challenge. This article aims to 
      provide researchers and clinicians with an up-to-date view on DC biology and its 
      relevance to pulmonary medicine. A developing trend in the field of DCs is the 
      shift from fundamental immunologic research toward exciting clinical insights and 
      applications. For the pulmonary clinician, this heralds the dawn of promising 
      therapies in various domains such as infections, allergy, and cancer.
FAU - Vermaelen, Karim
AU  - Vermaelen K
AD  - Department of Respiratory Diseases, Ghent University Hospital, 7K12ie, De 
      Pintelaan 185, Ghent B-9000, Belgium. karim.vermaelen@ugent.be
FAU - Pauwels, Romain
AU  - Pauwels R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20050505
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Chemokines)
SB  - IM
MH  - Chemokines/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lung/*immunology
MH  - Lung Diseases/*immunology
RF  - 265
EDAT- 2005/05/10 09:00
MHDA- 2005/11/11 09:00
CRDT- 2005/05/10 09:00
PHST- 2005/05/10 09:00 [pubmed]
PHST- 2005/11/11 09:00 [medline]
PHST- 2005/05/10 09:00 [entrez]
AID - 200410-1384SO [pii]
AID - 10.1164/rccm.200410-1384SO [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2005 Sep 1;172(5):530-51. doi: 
      10.1164/rccm.200410-1384SO. Epub 2005 May 5.