PMID- 15880127
OWN - NLM
STAT- MEDLINE
DCOM- 20051006
LR  - 20061115
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 35
IP  - 12
DP  - 2005 Jun
TI  - Longitudinal follow-up of body composition in hematopoietic stem cell transplant 
      patients.
PG  - 1171-7
AB  - Patients with hematological malignancies are well nourished prior to allogeneic 
      hematopoietic stem cell transplantation (HSCT). HSCT and associated complications 
      can affect body composition. The study evaluated cross-sectionally the prevalence 
      and longitudinally the changes in lean body mass index (LBMI) in HSCT patients. 
      Patients (n=82) were classified as normal or low LBMI. Logistic regression 
      analyses were used to estimate odds ratios (OR) for low vs normal LBMI, between 
      healthy volunteers and patients; for limited or extensive vs no chronic 
      graft-versus-host-disease (GVHD); and for decreased (Karnofsky <80) vs normal 
      functional status (>80). Patients were significantly more likely to have low LBMI 
      at 6, 12 months, 2-3, 4-6 and >6 years than volunteers. In all, 38% of patients 
      were below pre-HSCT LBMI at 4-6 years post-HSCT. Low LBMI was significantly 
      associated with steroid treatment (OR 2.6, confidence intervals (CI) 1.3-5.2, 
      P=0.008); limited (OR 5.5, CI 1.7-18.5, P=0.005) or extensive chronic GVHD (OR 
      20.3, CI 5.7-71.6, P<0.001); and decreased performance status (Karnofsky scores 
      of < or =80) (OR 2.7, CI 1.3-5.9, P=0.01). Patients were more likely to have low 
      LBMI than volunteers. Chronic GVHD and low performance status were associated 
      with low LBMI; thus, complications and/or treatment increase the likelihood of 
      low LBMI.
FAU - Kyle, U G
AU  - Kyle UG
AD  - Division of Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland.
FAU - Chalandon, Y
AU  - Chalandon Y
FAU - Miralbell, R
AU  - Miralbell R
FAU - Karsegard, V L
AU  - Karsegard VL
FAU - Hans, D
AU  - Hans D
FAU - Trombetti, A
AU  - Trombetti A
FAU - Rizzoli, R
AU  - Rizzoli R
FAU - Helg, C
AU  - Helg C
FAU - Pichard, C
AU  - Pichard C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Steroids)
SB  - IM
MH  - *Body Composition
MH  - Bone Marrow Transplantation/adverse effects
MH  - Case-Control Studies
MH  - Graft vs Host Disease
MH  - Hematologic Neoplasms/complications/metabolism/therapy
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Karnofsky Performance Status
MH  - Longitudinal Studies
MH  - Odds Ratio
MH  - Retrospective Studies
MH  - Steroids/adverse effects/therapeutic use
MH  - Transplantation, Homologous
EDAT- 2005/05/10 09:00
MHDA- 2005/10/07 09:00
CRDT- 2005/05/10 09:00
PHST- 2005/05/10 09:00 [pubmed]
PHST- 2005/10/07 09:00 [medline]
PHST- 2005/05/10 09:00 [entrez]
AID - 1704996 [pii]
AID - 10.1038/sj.bmt.1704996 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2005 Jun;35(12):1171-7. doi: 10.1038/sj.bmt.1704996.